Absorption
When found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid.
Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%.
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Famous quotes containing the word absorption:
“The great social adventure of America is no longer the conquest of the wilderness but the absorption of fifty different peoples.”
—Walter Lippmann (1889–1974)
“These philosophers dwell on the inevitability and unchangeableness of laws, on the power of temperament and constitution, the three goon, or qualities, and the circumstances, or birth and affinity. The end is an immense consolation; eternal absorption in Brahma.”
—Henry David Thoreau (1817–1862)
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—Anne Frank (1929–1945)