An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following removal of the spleen. The infections are typically characterized by either meningitis or sepsis, and are caused by encapsulated organisms including Streptococcus pneumoniae.
The risk of OPSI is 0.23–0.42 percent per year, with a lifetime risk of 5 percent. Most infections occur in the first few years following splenectomy, but the risk of OPSI is lifelong. OPSI is nearly uniformly fatal without treatment, and modern treatment has decreased the mortality to approximately 40–70 percent. Individuals with OPSI are most commonly treated with antibiotics and supportive care. Measures to prevent OPSI include vaccination and prophylactic antibiotics.
Read more about Overwhelming Post-splenectomy Infection: Mechanism
Famous quotes containing the words overwhelming and/or infection:
“Syntax and vocabulary are overwhelming constraints—the rules that run us. Language is using us to talk—we think we’re using the language, but language is doing the thinking, we’re its slavish agents.”
—Harry Mathews (b. 1930)
“This royal throne of kings, this sceptred isle,
This earth of majesty, this seat of Mars,
This other Eden, demi-paradise,
This fortress built by nature for herself
Against infection and the hand of war,
This happy breed of men, this little world,
This precious stone set in the silver sea,
Which serves it in the office of a wall,
Or as a moat defensive to a house
Against the envy of less happier lands;
This blessèd plot, this earth, this realm, this England.”
—William Shakespeare (1564–1616)