Types
There are eight different types of OI, Type I being the most common, though the symptoms vary from person to person.
| Type | Description | Gene | OMIM | Mode of Inheritance |
| I | mild | Null COL1A1 allele | 166240 (IA), 166200 (IB) | autosomal dominant, 60% de novo |
| II | severe and usually lethal in the perinatal period | COL1A1, COL1A2, | 166210 (IIA), 610854 (IIB) | autosomal dominant, ~100% de novo |
| III | considered progressive and deforming | COL1A1, COL1A2 | 259420 | autosomal dominant, ~100% de novo |
| IV | deforming, but with normal scleras | COL1A1, COL1A2 | 166220 | autosomal dominant, 60% de novo |
| V | shares the same clinical features of IV, but has unique histologic findings ("mesh-like") | unknown | 610967 | autosomal dominant |
| VI | shares the same clinical features of IV, but has unique histologic findings ("fish scale") | unknown | 610968 | unknown |
| VII | associated with cartilage associated protein | CRTAP | 610682 | autosomal recessive |
| VIII | severe to lethal, associated with the protein leprecan | LEPRE1 | 610915 | autosomal recessive |
Read more about this topic: Osteogenesis Imperfecta
Famous quotes containing the word types:
“... there are two types of happiness and I have chosen that of the murderers. For I am happy. There was a time when I thought I had reached the limit of distress. Beyond that limit, there is a sterile and magnificent happiness.”
—Albert Camus (1913–1960)
“The bourgeoisie loves so-called “positive” types and novels with happy endings since they lull one into thinking that it is fine to simultaneously acquire capital and maintain one’s innocence, to be a beast and still be happy.”
—Anton Pavlovich Chekhov (1860–1904)
“Science is intimately integrated with the whole social structure and cultural tradition. They mutually support one other—only in certain types of society can science flourish, and conversely without a continuous and healthy development and application of science such a society cannot function properly.”
—Talcott Parsons (1902–1979)