Types
There are eight different types of OI, Type I being the most common, though the symptoms vary from person to person.
| Type | Description | Gene | OMIM | Mode of Inheritance |
| I | mild | Null COL1A1 allele | 166240 (IA), 166200 (IB) | autosomal dominant, 60% de novo |
| II | severe and usually lethal in the perinatal period | COL1A1, COL1A2, | 166210 (IIA), 610854 (IIB) | autosomal dominant, ~100% de novo |
| III | considered progressive and deforming | COL1A1, COL1A2 | 259420 | autosomal dominant, ~100% de novo |
| IV | deforming, but with normal scleras | COL1A1, COL1A2 | 166220 | autosomal dominant, 60% de novo |
| V | shares the same clinical features of IV, but has unique histologic findings ("mesh-like") | unknown | 610967 | autosomal dominant |
| VI | shares the same clinical features of IV, but has unique histologic findings ("fish scale") | unknown | 610968 | unknown |
| VII | associated with cartilage associated protein | CRTAP | 610682 | autosomal recessive |
| VIII | severe to lethal, associated with the protein leprecan | LEPRE1 | 610915 | autosomal recessive |
Read more about this topic: Osteogenesis Imperfecta
Famous quotes containing the word types:
“The American man is a very simple and cheap mechanism. The American woman I find a complicated and expensive one. Contrasts of feminine types are possible. I am not absolutely sure that there is more than one American man.”
—Henry Brooks Adams (1838–1918)
“Our major universities are now stuck with an army of pedestrian, toadying careerists, Fifties types who wave around Sixties banners to conceal their record of ruthless, beaverlike tunneling to the top.”
—Camille Paglia (b. 1947)
“The rank and file have let their servants become their masters and dictators.... Provision should be made in all union constitutions for the recall of leaders. Big salaries should not be paid. Career hunters should be driven out, as well as leaders who use labor for political ends. These types are menaces to the advancement of labor.”
—Mother Jones (1830–1930)