Deficiency
If a person is deficient in OTC, ammonia levels will build up, and this will cause neurological problems. Levels of the amino acids glutamate and alanine will be increased (as these are the amino acids that receive nitrogen from others).
Levels of urea cycle intermediates may be decreased, as carbamoyl phosphate cannot replenish the cycle. The carbamoyl phosphate instead goes into the uridine monophosphate synthetic pathway. Here orotic acid (one step of this alternative pathway) levels in the blood are increased.
A potential treatment for the high ammonia levels is to give sodium benzoate, which combines with glycine to produce hippurate, at the same time removing an ammonium group. Biotin also plays an important role in the functioning of the OTC enzyme and has been shown to reduce ammonia intoxication in animal experiments.
Read more about this topic: Ornithine Transcarbamylase
Famous quotes containing the word deficiency:
“Free verse leaves out the meter and makes up
For the deficiency by church intoning.
Free verse, so called, is really cherished prose....”
—Robert Frost (1874–1963)
“All rejection and negation indicates a deficiency in fertility: fundamentally, if only we were good plowland we would allow nothing to go unused, and in every thing, event, and person we would welcome manure, rain, or sunshine.”
—Friedrich Nietzsche (1844–1900)
“Shakespeare’s fault is not the greatest into which a poet may fall. It merely indicates a deficiency of taste.”
—Denis Diderot (1713–1784)