The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes in the brain which is involved in the cognitive processing of decision-making. In non-human primates it consists of the association cortex areas Brodmann area 11, 12 and 13; in humans it consists of Brodmann area 10, 11 and 47 Because of its functions in emotion and reward, the OFC is considered by some to be a part of the limbic system.
The OFC anatomically is defined as the part of the prefrontal cortex that receives projections from the magnocellular, medial nucleus of the mediodorsal thalamus. It gets its name from its position immediately above the orbits in which the eyes are located. Considerable individual variability has been found in the OFC of both humans and non-human primates. A related area is found in rodents.
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Read more about Orbitofrontal Cortex: Functional Connectivity of The Orbitofrontal Cortex, Clinical Applications of OFC Connectivity Disruptions, Orbitofrontal Cortex and Addiction, Anatomy of OFC and Addiction, OFC and Addiction in Animal Studies, Neuroimaging Research in Healthy Participants, Consequences of Damage To The OFC