Ontology Engineering in Life Sciences
Life sciences is flourishing with ontologies that biologists use to make sense of their experiments. For inferring correct conclusions from experiments, ontologies have to be structured optimally against the knowledge base they represent. The structure of an ontology needs to be changed continuously so that it is an accurate representation of the underlying domain.
Recently, an automated method was introduced for engineering ontologies in life sciences such as Gene Ontology (GO), one of the most successful and widely used biomedical ontology. Based on information theory, it restructures ontologies so that the levels represent the desired specificity of the concepts. Similar information theoretic approaches have also been used for optimal partition of Gene Ontology. Given the mathematical nature of such engineering algorithms, these optimizations can be automated to produce a principled and scalable architecture to restructure ontologies such as GO.
Open Biomedical Ontologies (OBO), a 2006 initiative of the U.S. National Center for Biomedical Ontology, that provides a common 'foundry' for various ontology initiatives, amongst which are:
- The Generic Model Organism Project (GMOD)
- Gene Ontology Consortium
- Sequence Ontology
- Ontology Lookup Service
- The Plant Ontology Consortium
- Standards and Ontologies for Functional Genomics
and more
Read more about this topic: Ontology Engineering
Famous quotes containing the words engineering, life and/or sciences:
“Mining today is an affair of mathematics, of finance, of the latest in engineering skill. Cautious men behind polished desks in San Francisco figure out in advance the amount of metal to a cubic yard, the number of yards washed a day, the cost of each operation. They have no need of grubstakes.”
—Merle Colby, U.S. public relief program (1935-1943)
“A tree is beautiful, but what’s more, it has a right to life; like water, the sun and the stars, it is essential. Life on earth is inconceivable without trees. Forests create climate, climate influences peoples’ character, and so on and so forth. There can be neither civilization nor happiness if forests crash down under the axe, if the climate is harsh and severe, if people are also harsh and severe.... What a terrible future!”
—Anton Pavlovich Chekhov (1860–1904)
“I am not able to instruct you. I can only tell that I have chosen wrong. I have passed my time in study without experience; in the attainment of sciences which can, for the most part, be but remotely useful to mankind. I have purchased knowledge at the expense of all the common comforts of life: I have missed the endearing elegance of female friendship, and the happy commerce of domestic tenderness.”
—Samuel Johnson (1709–1784)