Endogenous Remyelination
Spontaneous myelin repair was first observed in feline models, but was later discovered to occur in the human central nervous system as well, specifically in cases of multiple sclerosis. Spontaneous myelin repair does not result in morphologically normal oligodendrocytes and is associated with thinner myelin compared to axonal diameter than normal myelin. Despite morphological abnormalities, however, remyelination does restore normal conduction, and comparative studies of cortical lesions reported a greater proportion of remyelination in the cortex as opposed to white matter lesions.
Read more about this topic: Oligodendrocyte Progenitor