Nucleus pulposus is the jelly-like substance in the middle of the spinal disc. It is the remnant of the notochord. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocyte-like cells, collagen fibrils, and proteoglycan aggrecans that aggregate through hyaluronic chains. Attached to each aggrecan molecule are the glycosaminoglycan (GAG) chains of chondroitin sulfate and keratan sulfate. Aggrecan is negatively charged and hydrophilic. This property allows it to draw water into the Nucleus Pulposus.
Famous quotes containing the word nucleus:
“Just see how it glints and sparkles. Of course it is a nucleus and focus of crime. Every good stone is. They are the devil’s pet baits. In larger and older jewels every facet may stand for a bloody deed....”
—Sir Arthur Conan Doyle (1859–1930)