Nucleotide Excision Repair - NER Associated Genes

NER Associated Genes

Human Gene (Protein) Mouse Ortholog Yeast Ortholog Subpathway Function in NER GeneCards Entry
CCNH (Cyclin H) Ccnh CCL1 Both CDK Activator Kinase (CAK) subunit CCNH
CDK7 (Cyclin Dependent Kinase (CDK) 7)) Cdk7 KIN28 Both CDK7
CETN2 (Centrin-2) Cetn2 Unknown GGR damage recognition; forms complex with XPC CETN2
DDB1 (DDB1) Ddb1 Unknown GGR damage recognition; forms complex with DDB2 DDB1
DDB2 (DDB2) Ddb2/Xpe Unknown GGR damage recognition; recruits XPC DDB2
ERCC1 (ERCC1) Ercc1 RAD10 Both Involved in incision on 3' side of damage; forms complex with XPF ERCC1
ERCC2 (XPD) Ercc2 RAD3 Both ATPase and helicase activity; transcription factor II H (TFIIH) subunit ERCC2
ERCC3 (XPB) Ercc3 RAD25 Both ATPase and helicase activity; transcription factor II H (TFIIH) subunit ERCC3
ERCC4 (XPF) Ercc4 RAD1 Both Involved in incision on 3' side of damage; structure specific endonuclease ERCC4
ERCC5 (XPG) Ercc5 RAD2 Both Involved in incision on 5' side of damage; stabilizes TFIIH; structure specific endonuclease ERCC5
ERCC6 (CSB) Ercc6 RAD26 TC-NER transcription elongation factor; involved in transcription coupling and chromatin remodelling ERCC6
ERCC8 (CSA) Ercc8 RAD28 TC-NER ubiquitin ligase complex; interacts with CSB and p44 of TFIIH ERCC8
LIG1 (DNA Ligase I) Lig1 CDC9 Both LIG1
MNAT1 (MNAT1) Mnat1 TFB3 Both Stabilizes CAK complex MNAT1
MMS19 (MMS19) Mms19 MET18 Both Interacts with XPD and XPB subunits of TFIIH helicases MMS19
RAD23A (RAD23A) Rad23a RAD23 GGR damage recognition; forms complex with XPC RAD23A
RAD23B (RAD23B) Rad23b RAD23 GGR damage recognition, forms complex with XPC RAD23B
RPA1 (RPA1) Rpa1 RFA1 Both subunit of RFA complex RPA1
RPA2 (RPA2) Rpa2 RFA2 Both subunit of RFA complex RPA2
TFIIH (Transcription factor II H) Unknown Unknown Both No GeneCards
XAB2 (XAB2) Xab2 SYF1 TC-NER damage recognition; interacts with XPA, CSA, and CSB XAB2
XPA (XPA) Xpa RAD14 Both damage recognition XPA
XPC (XPC) Xpc RAD4 GGR damage recognition XPC

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