Role and Interaction Aspects
The nuclear lamina is assembled by interactions of two lamin polypeptides in which the α-helical regions are wound around each other to form a two stranded α-helical coiled-coil structure, followed by a head-to-tail association of the multiple dimers. The linearly elongated polymer is extended laterally by a side-by-side association of polymers, resulting in a 2D structure underlying the nuclear envelope. Next to providing mechanical support to the nucleus, the nuclear lamina plays an essential role in chromatin organization, cell cycle regulation, DNA replication, cell differentiation and apoptosis.
Read more about this topic: Nuclear Lamina
Famous quotes containing the words role and, role, interaction and/or aspects:
“This [new] period of parenting is an intense one. Never will we know such responsibility, such productive and hard work, such potential for isolation in the caretaking role and such intimacy and close involvement in the growth and development of another human being.”
—Joan Sheingold Ditzion and Dennie Palmer (20th century)
“To win by strategy is no less the role of a general than to win by arms.”
—Julius Caesar [Gaius Julius Caesar] (10044 B.C.)
“Here is this vast, savage, howling mother of ours, Nature, lying all around, with such beauty, and such affection for her children, as the leopard; and yet we are so early weaned from her breast to society, to that culture which is exclusively an interaction of man on man,a sort of breeding in and in, which produces at most a merely English nobility, a civilization destined to have a speedy limit.”
—Henry David Thoreau (18171862)
“I suppose an entire cabinet of shells would be an expression of the whole human mind; a Flora of the whole globe would be so likewise, or a history of beasts; or a painting of all the aspects of the clouds. Everything is significant.”
—Ralph Waldo Emerson (18031882)