Nuclear Lamina - Laminopathies

Laminopathies

Defects in the genes encoding for nuclear lamin (such as lamin A and lamin B1) have been implicated in a variety of diseases (laminopathies) such as:

  • Emery-Dreifuss muscular dystrophy - A muscle wasting disease
  • Progeria - Premature aging
  • Restrictive dermopathy - A disease associated with extremely tight skin and other severe neonatal abnormalities

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