The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis and its activity is inhibited by Numb to promote neural differentiation.
Read more about Notch Signaling Pathway: Discovery, Mechanism of Action, Function, Pathway, Notch Signaling in Embryogenesis, Notch Signaling in Central Nervous System Development and Function, Notch Signaling in Cardiovascular Development, Notch Signaling in Endocrine Development
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