Non-competitive Inhibition - Example: Noncompetitive Inhibitors of CYP2C9 Enzyme

Example: Noncompetitive Inhibitors of CYP2C9 Enzyme

Noncompetitive inhibitors of CYP2C9 enzyme include nifedipine, tranylcypromine, phenethyl isothiocyanate, and 6-hydroxyflavone. Computer docking simulation and constructed mutants substituted indicate that the noncompetitive binding site of 6-hydroxyflavone is the reported allosteric binding site of CYP2C9 enzyme.