Products of Nicotinic Agonist
| Active ingredient | Product name | Chemical name | Pharmaceutical form | Pharmacodynamic properties | Therapeutic use | Structure |
|---|---|---|---|---|---|---|
| Varenicline tartrate | Champix, Chantix | 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazinobenzazepine | Film coated tablet | Partial agonist of the nicotinic acetylcholine receptor, subtype α4β2 | Treatment of tobacco dependence | |
| Galantamine hydrobromide | Reminyl, Nivalin, Razadyne and Razadyn ER | 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro-benzazepin-6-ol | Sustained release capsule, film coated tablet, oral solution | Cholinesterasa inhibitor and a noncompetative agonist of the nicotinic acetylcholine receptor | Treatment of dementia caused by Alzheimer's disease | |
| Nicotine | Nicorette, Nicotinell, Niquitin, Boots NicAssist, Commit, Habitrol, Nicoderm CQ, Nicotrol, Thrive | 3-pyridine | Transdermal patch, gum, inhaler, nasal spray, lozenge, microtab | Agonist of the nicotinic receptor, both Ganglion type and α4β2 | Treatment of tobacco dependence | |
| Carbachol | Miostat | 2--N,N,N-trimethylethanaminium | Intraocular solution | Cholinergic agonist | Treatment of glaucoma | |
| Suxamethonium chloride (Succinylcholine chloride) | Anectine, Quelicin Suxamethonium Chloride | 2,2'-bis(N,N,N-trimethylethanaminium) | Intravenous or intramuscular injection | Depolarizing neuromuscular blocking agent | Short acting muscle relaxant | |
| Epibatidine | Not listed | 2-(6-chloropyridin-3-yl)-7-azabicycloheptane | Not listed | Agonist of the nicotinic acetylcholine receptor | Not used as a drug |
Other nicotinic agonists, albeit generally with limited clinical use, include:
- lobeline, an agonist on Ganglion type nicotinic receptors and also affects sensory nerve terminals
- epibatidine, and agonist on Ganglion type, α4β2 and α7 receptors.
- decamethonium causes depolarization block on muscle type receptors, similarly to suxamethonium
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Famous quotes containing the words products of and/or products:
“It seemed there was a sort of poisoning, an auto-infection of the organisms, so Dr. Krokowski said; it was caused by the disintegration of a substance ... and the products of this disintegration operated like an intoxicant upon the nerve-centres of the spinal cord, with an effect similar to that of certain poisons, such as morphia, or cocaine.”
—Thomas Mann (1875–1955)
“It seemed there was a sort of poisoning, an auto-infection of the organisms, so Dr. Krokowski said; it was caused by the disintegration of a substance ... and the products of this disintegration operated like an intoxicant upon the nerve-centres of the spinal cord, with an effect similar to that of certain poisons, such as morphia, or cocaine.”
—Thomas Mann (1875–1955)