Nicotinic Versus Muscarinic Activity
| Comparison of cholinergic agonists | ||||
|---|---|---|---|---|
| Substance | Receptor specificity | Hydrolysis by acetylcholinesterase |
Comments | |
| Muscarinic | Nicotinic | |||
| Choline | +++ | +++ | ++ | Essential nutrient |
| Acetylcholine | +++ | +++ | +++ | Endogenous ligand |
| Carbachol | ++ | +++ | - | Used in the treatment of glaucoma |
| Methacholine | +++ | + | ++ | |
| Bethanechol | +++ | - | - | Used in bladder and gastrointestinal hypotonia. |
| Muscarine | +++ | - | - | Natural alkaloid found in certain mushrooms. Cause of mushroom poisoning |
| Nicotine | - | +++ | - | Natural alkaloid found in the tobacco plant. |
| Pilocarpine | ++ | - | - | Used in glaucoma |
| Oxotremorine | ++ | - | - | |
Read more about this topic: Nicotinic Agonist
Famous quotes containing the word activity:
“To play is nothing but the imitative substitution of a pleasurable, superfluous and voluntary action for a serious, necessary, imperative and difficult one. At the cradle of play as well as of artistic activity there stood leisure, tedium entailed by increased spiritual mobility, a horror vacui, the need of letting forms no longer imprisoned move freely, of filling empty time with sequences of notes, empty space with sequences of form.”
—Max J. Friedländer (1867–1958)