Early Life and Activities
Born in Bucharest, he was the first of four children of father Costache Paulescu and mother Maria Paulescu. He displayed remarkable abilities as early as his first school years. He learned French, Latin and Ancient Greek at an early age, so that a few years later he became fluent in all these languages and was able to read classical works of Latin and Greek literature in the original. He also had a particular gift for drawing and music and special inclinations towards natural sciences, such as physics and chemistry. He graduated from the Mihai Viteazu High School in Bucharest, in 1888.
In the autumn of 1888, Paulescu left for Paris, where he enrolled in medical school. In 1897 he graduated with a Doctor of Medicine degree, and was immediately appointed as assistant surgeon at the Notre-Dame du Perpétuel-Secours Hospital. In 1900, Paulescu returned to Romania, where he remained until his death (1931) as Head of the Physiology Department of the University of Bucharest Medical School, as well as a Professor of Clinical Medicine at the St. Vincent de Paul Hospital in Bucharest.
In 1916, he succeeded in developing an aqueous pancreatic extract which, when injected into a diabetic dog, proved to have a normalizing effect on blood sugar levels. After a gap during World War I, he resumed his research.
From April 24 to June 23, 1921, Paulescu published four papers at the Romanian Section of the Society of Biology in Paris:
- The effect of the pancreatic extract injected into a diabetic animal by way of the blood.
- The influence of the time elapsed from the intravenous pancreatic injection into a diabetic animal.
- The effect of the pancreatic extract injected into a normal animal by way of the blood.
An extensive paper on this subject - Research on the Role of the Pancreas in Food Assimilation - was submitted by Paulescu on June 22 to the Archives Internationales de Physiologie in Liège, Belgium, and was published in the August 1921 issue of this journal.
The method used by Paulescu to prepare his pancreatic extract, as published in the Archives Internationales de Physiologie in 1921, was similar to a procedure described by the American researcher Israel S. Kleiner in an article published in 1919 in Journal of Biological Chemistry. Using his procedure, Kleiner had been able to demonstrate significant reductions in the concentration of blood and urinary glucose after intravenous injections of his extract.
Furthermore, Paulescu secured the patent rights for his method of manufacturing pancreine on April 10, 1922 (patent no. 6254) from the Romanian Ministry of Industry and Trade.
Read more about this topic: Nicolae Paulescu
Famous quotes containing the words early, life and/or activities:
“The shift from the perception of the child as innocent to the perception of the child as competent has greatly increased the demands on contemporary children for maturity, for participating in competitive sports, for early academic achievement, and for protecting themselves against adults who might do them harm. While children might be able to cope with any one of those demands taken singly, taken together they often exceed children’s adaptive capacity.”
—David Elkind (20th century)
“Mine honor is my life, both grow in one,
Take honor from me, and my life is done.”
—William Shakespeare (1564–1616)
“There is, I think, no point in the philosophy of progressive education which is sounder than its emphasis upon the importance of the participation of the learner in the formation of the purposes which direct his activities in the learning process, just as there is no defect in traditional education greater than its failure to secure the active cooperation of the pupil in construction of the purposes involved in his studying.”
—John Dewey (1859–1952)