Filmography
| Year | Title | Role | Notes |
|---|---|---|---|
| 1959 | Porgy and Bess | cameo | (uncredited) |
| 1964 | The Lieutenant (TV) | Norma Bartlett | |
| 1966 | Tarzan: The Deadly Silence Parts 1 & 2 (TV) | Ruana | starring Ron Ely |
| 1966 | Mister Buddwing | Dice Player | starring James Garner |
| 1966 | Star Trek (TV) | Lt. Uhura | 1966–1969 |
| 1967 | Doctor, You've Got to be Kidding | Jenny Ribbock | starring Sandra Dee |
| 1973 | Star Trek: The Animated Series (TV) | Lt. Uhura/Additional voices | |
| 1974 | Truck Turner | Dorinda | |
| 1979 | Star Trek: The Motion Picture | Lt. Cmdr. Uhura | |
| 1982 | Star Trek II: The Wrath of Khan | Cmdr. Uhura | |
| 1983 | Antony and Cleopatra | Charmian - Maid of Honour | |
| 1984 | Star Trek III: The Search for Spock | Cmdr. Uhura | |
| 1986 | Star Trek IV: The Voyage Home | Cmdr. Uhura | |
| The Supernaturals (horror film) | Sgt. Leona Hawkins | ||
| 1989 | Star Trek V: The Final Frontier | Cmdr. Uhura | |
| 1991 | Star Trek VI: The Undiscovered Country | Cmdr. Uhura | |
| 1992 | Star Trek: 25th Anniversary Enhanced (VG) | Lt. Uhura | |
| 1994 | Gargoyles (TV) | Diane Maza | Guest star in four episodes through 1998 |
| Batman: The Animated Series (TV) | Thoth Khepera | "Avatar" | |
| Star Trek: Judgment Rites (VG) | Lt. Uhura | ||
| 2000 | Futurama (TV) | Herself | Anthology of Interest I |
| 2002 | Futurama (TV) | Herself | Where No Fan Has Gone Before |
| Snow Dogs | Amelia Brooks | ||
| 2005 | Are We There Yet? | Miss Mable | |
| 2007 | Escape from Heaven (announced) | Jules | |
| Star Trek: Of Gods and Men | Capt. Uhura | ||
| Heroes | Nana Dawson | ||
| 2008 | Lady Magdalene's | Lady Magdalene / Maggie | |
| Tru Loved | Grandma | ||
| The Torturer | Doc |
In 2009, Nichols presented the Best Actress Award with Zoe Saldana to Taraji Henson at the 9th Annual BET Awards.
Read more about this topic: Nichelle Nichols