Neural Darwinism

Neural Darwinism, a large scale theory of brain function by Gerald Edelman, was initially published in 1978, in a book called The Mindful Brain (MIT Press). It was extended and published in the 1989 book Neural Darwinism – The Theory of Neuronal Group Selection.

Edelman was awarded the Nobel Prize in 1972 for his work in immunology showing how the population of lymphocytes capable of binding to a foreign antigen is increased by differential clonal multiplication following antigen discovery. Essentially, this proved that the human body is capable of creating complex adaptive systems as a result of local events with feedback. Edelman's interest in selective systems expanded into the fields of neurobiology and neurophysiology, and in Neural Darwinism, Edelman puts forth a theory called "neuronal group selection". It contains three major parts:

1. Anatomical connectivity in the brain occurs via selective mechanochemical events that take place epigenetically during development. This creates a diverse primary repertoire by differential reproduction.
2. Once structural diversity is established anatomically, a second selective process occurs during postnatal behavioral experience through epigenetic modifications in the strength of synaptic connections between neuronal groups. This creates a diverse secondary repertoire by differential amplification.
3. Reentrant signaling between neuronal groups allows for spatiotemporal continuity in response to real-world interactions.