Treatment
Treat any underlying cause, allow the patient to drink as much as required. Correct metabolic abnormalities. The first line of treatment is hydrochlorothiazide and amiloride. Consider a low-salt and low-protein diet.
In nephrogenic Diabetes Inspidus caused by lithium (seen in bipolar patients for example), K-sparing diuretics such as amiloride would be used. The goal in this case is to excrete lithium. Using Hydrochlorothiazide in this case would increase aldosterone, which would lead to increased sodium retention (and lithium as well).
Read more about this topic: Nephrogenic Diabetes Insipidus
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—Rutherford Birchard Hayes (1822–1893)
“If the study of all these sciences, which we have enumerated, should ever bring us to their mutual association and relationship, and teach us the nature of the ties which bind them together, I believe that the diligent treatment of them will forward the objects which we have in view, and that the labor, which otherwise would be fruitless, will be well bestowed.”
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“Any important disease whose causality is murky, and for which treatment is ineffectual, tends to be awash in significance.”
—Susan Sontag (b. 1933)