Screening of Natural Products
Pharmacognosy provides the tools to identify, select and process natural products destined for medicinal use. Usually, the natural product compound has some form of biological activity and that compound is known as the active principle - such a structure can act as a lead compound (not to be confused with compounds containing the element lead). Many of today's medicines are obtained directly from a natural source.
On the other hand, some medicines are developed from a lead compound originally obtained from a natural source. This means the lead compound:
- can be produced by total synthesis, or
- can be a starting point (precursor) for a semisynthetic compound, or
- can act as a template for a structurally different total synthetic compound.
This is because most biologically active natural product compounds are secondary metabolites with very complex structures. This has an advantage in that they are extremely novel compounds but this complexity also makes many lead compounds' synthesis difficult and the compound usually has to be extracted from its natural source - a slow, expensive and inefficient process. As a result, there is usually an advantage in designing simpler analogues.
Read more about this topic: Natural Product
Famous quotes containing the words natural and/or products:
“Modern morality and manners suppress all natural instincts, keep people ignorant of the facts of nature and make them fighting drunk on bogey tales.”
—Aleister Crowley (1875–1947)
“The measure discriminates definitely against products which make up what has been universally considered a program of safe farming. The bill upholds as ideals of American farming the men who grow cotton, corn, rice, swine, tobacco, or wheat and nothing else. These are to be given special favors at the expense of the farmer who has toiled for years to build up a constructive farming enterprise to include a variety of crops and livestock.”
—Calvin Coolidge (1872–1933)