Native chemical ligation or NCL is an important extension of the chemical ligation field, a concept for constructing a large polypeptide formed by the assembling of two or more unprotected peptides segments. Especially, NCL is the most powerful ligation method for synthesizing native backbone proteins or modified proteins of moderate size (i.e., small proteins< 200 AA).
Read more about Native Chemical Ligation: Definition, Historical Context, Properties
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