The Volozhin Yeshiva
Berlin led the yeshiva in Volozhin (in what is presently Belarus), then the largest institution of its kind, from 1854 to its closure in 1892. Despite the destruction (twice) of the town and the yeshiva building in large fires, its enrollment increased steadily under his leadership, and the yeshiva would produce a number of prominent rabbinic figures who led Eastern European Jewry until World War II. Amongst them was Rabbi Shimon Shkop.
In Volozhin, his leadership was contested by the popular Rabbi Joseph Dov (Yoshe Ber) Soloveitchik, whose style of Torah study differed substationally from Rabbi Berlin's. Rabbi J.D. Soloveitchik ultimately became rabbi of Slutsk, Warsaw and Brisk, where he founded the rabbinical dynasty that still carries his name.
In 1892, the Volozhin yeshiva shut down. Russian authorities (influenced by Haskalah elements) sought to introduce secular studies into the yeshiva. Berlin was willing to initially accept some secular studies. However, the requirements became more and more onerous with the government eventually stipulating that "All teachers of all subjects must have college diplomas ... no Judaic subjects may be taught between 9 AM and 3 PM ... no night classes are allowed ... total hours of study per day may not exceed ten." Faced with these restrictions, Berlin chose to close the Yeshiva.
Read more about this topic: Naftali Zvi Yehuda Berlin