Comparison
Percentages in table below refer to how large fraction of people with the MEN type develop the neoplasia type.
| Feature | MEN 1 | MEN 2 | ||
|---|---|---|---|---|
| MEN 2A | MEN 2B | FMTC | ||
| Eponym | Wermer syndrome | Sipple syndrome | (multiple) | (none) |
| OMIM | 131100 | 171400 | 162300 | 155240 |
| Pancreatic tumors | gastrinoma (50%), insulinoma (20%), vipoma, glucagonoma, PPoma |
- | - | - |
| Pituitary adenoma | 66% | - | - | - |
| Angiofibroma | 64%* | - | - | - |
| Lipoma | 17%* | - | - | - |
| Parathyroid hyperplasia | 90% | 50% | - | - |
| Medullary thyroid carcinoma | - | 100% | 85% | 100% |
| Pheochromocytoma | - | >33% | 50% | - |
| Marfanoid body habitus | - | - | 80% | - |
| Mucosal neuroma | - | - | 100% | - |
| Gene(s) | MEN1 (131100) | RET (164761) | RET (164761) | RET (164761), NTRK1 (191315) |
| Approx. prevalence | 1 in 35,000 (1 in 20,000 to 1 in 40,000) |
1 in 40,000 | 1 in 40,000 | |
| Initial description (year) | 1954 | 1961 | 1965 | |
*- of patients with MEN1 and gastrinoma
FMTC = familial medullary thyroid cancer
MEN 2B is sometimes known as MEN 3 and the designation varies by institution (c.f. www.ClinicalReview.com). Although a variety of additional eponyms have been proposed for MEN2B (e.g. Williams-Pollock syndrome, Gorlin-Vickers syndrome, and Wagenmann–Froboese syndrome), none ever gained sufficient traction to merit continued use and, indeed, are all but abandoned in the medical literature. Another early report was Schimke et al. in 1968.
OMIM also includes a fourth form of multiple endocrine neoplasia ("MEN4"), associated with CDKN1B. The presentation is believed to overlap that of MEN1 and MEN2.
Read more about this topic: Multiple Endocrine Neoplasia
Famous quotes containing the word comparison:
“Most parents aren’t even aware of how often they compare their children. . . . Comparisons carry the suggestion that specific conditions exist for parental love and acceptance. Thus, even when one child comes out on top in a comparison she is left feeling uneasy about the tenuousness of her position and the possibility of faring less well in the next comparison.”
—Marianne E. Neifert (20th century)
“Intolerance respecting other people’s religion is toleration itself in comparison with intolerance respecting other people’s art.”
—Wallace Stevens (1879–1955)
“Clay answered the petition by declaring that while he looked on the institution of slavery as an evil, it was ‘nothing in comparison with the far greater evil which would inevitably flow from a sudden and indiscriminate emancipation.’”
—State of Indiana, U.S. public relief program (1935-1943)