Mother Brain may refer to the following fictional characters:
- Mother Brain (Metroid), a main antagonist in the Metroid video game series, and the crossover fiction Captain N: The Game Master cartoon show based on it
- A character in the video game Chrono Trigger
- A character in the video game Phantasy Star II
- A character in the video game I Wanna Be The Guy
Famous quotes containing the words mother and/or brain:
“Do you think your mother and I should have lived comfortably so long together, if ever we had been married? Baggage!”
—John Gay (1685–1732)
“Tenants of the house,
Thoughts of a dry brain in a dry season.”
—T.S. (Thomas Stearns)