Mother Brain may refer to the following fictional characters:
- Mother Brain (Metroid), a main antagonist in the Metroid video game series, and the crossover fiction Captain N: The Game Master cartoon show based on it
- A character in the video game Chrono Trigger
- A character in the video game Phantasy Star II
- A character in the video game I Wanna Be The Guy
Famous quotes containing the words mother and/or brain:
“His mother should have thrown him out and kept the stork.”
—Mae West, U.S. actor, screenwriter, and Leo McCarey. Ruby Carter (Mae West)
“I could brain him with his lady’s fan.”
—William Shakespeare (1564–1616)