Examples
For a more comprehensive list, see List of monoclonal antibodies. List of FDA approved therapeutic antibodies is found in Monoclonal antibody therapyBelow are examples of clinically important monoclonal antibodies.
| Main category | Type | Application | Mechanism/Target | Mode |
|---|---|---|---|---|
| Anti- inflammatory |
infliximab |
|
inhibits TNF-α | chimeric |
| adalimumab |
|
inhibits TNF-α | human | |
| basiliximab |
|
inhibits IL-2 on activated T cells | chimeric | |
| daclizumab |
|
inhibits IL-2 on activated T cells | humanized | |
| omalizumab |
|
inhibits human immunoglobulin E (IgE) | humanized | |
| Anti-cancer | gemtuzumab |
|
targets myeloid cell surface antigen CD33 on leukemia cells | humanized |
| alemtuzumab |
|
targets an antigen CD52 on T- and B-lymphocytes | humanized | |
| rituximab |
|
targets phosphoprotein CD20 on B lymphocytes | chimeric | |
| trastuzumab |
|
targets the HER2/neu (erbB2) receptor | humanized | |
| nimotuzumab |
|
EGFR inhibitor | Humanized | |
| cetuximab |
|
EGFR inhibitor | Chimeric | |
| bevacizumab |
|
inhibits VEGF | humanized | |
| Other | palivizumab |
|
inhibits an RSV fusion (F) protein | humanized |
| abciximab |
|
inhibits the receptor GpIIb/IIIa on platelets | chimeric |
Read more about this topic: Monoclonal Antibodies
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—Alexander Pope (1688–1744)
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—Bernard Mandeville (1670–1733)