Monoamine Oxidase Inhibitor - Mechanism of Action

Mechanism of Action

MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine, and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Dopamine is equally deaminated by both types. Many formulations have forms of fluoride attached to assist in permeating the blood–brain barrier, which is suspected as a factor in pineal gland effects.

Read more about this topic:  Monoamine Oxidase Inhibitor

Famous quotes containing the words mechanism of, mechanism and/or action:

    Life is an offensive, directed against the repetitious mechanism of the Universe.
    Alfred North Whitehead (1861–1947)

    When one of us dies of cancer, loses her mind, or commits suicide, we must not blame her for her inability to survive an ongoing political mechanism bent on the destruction of that human being. Sanity remains defined simply by the ability to cope with insane conditions.
    Ana Castillo (b. 1953)

    It is most pleasant to commit a just action which is disagreeable to someone whom one does not like.
    Victor Hugo (1802–1885)