The Driving Forces of Evolution
Depending on the relative importance assigned to the various forces of evolution, three perspectives provide evolutionary explanations for molecular evolution.
While recognizing the importance of random drift for silent mutations, selectionists hypotheses argue that balancing and positive selection are the driving forces of molecular evolution. Those hypotheses are often based on the broader view called panselectionism, the idea that selection is the only force strong enough to explain evolution, relaying random drift and mutations to minor roles.
Neutralists hypotheses emphasize the importance of mutation, purifying selection and random genetic drift. The introduction of the neutral theory by Kimura, quickly followed by King and Jukes' own findings, led to a fierce debate about the relevance of neodarwinism at the molecular level. The Neutral theory of molecular evolution states that most mutations are deleterious and quickly removed by natural selection, but of the remaining ones, the vast majority are neutral with respect to fitness while the amount of advantageous mutations is vanishingly small. The fate of neutral mutations are governed by genetic drift, and contribute to both nucleotide polymorphism and fixed differences between species.
Mutationists hypotheses emphasize random drift and biases in mutation patterns. Sueoka was the first to propose a modern mutationist view. He proposed that the variation in GC content was not the result of positive selection, but a consequence of the GC mutational pressure.
Read more about this topic: Molecular Evolution
Famous quotes containing the words driving, forces and/or evolution:
“Decisive inventions and discoveries always are initiated by an intellectual or moral stimulus as their actual motivating force, but, usually, the final impetus to human action is given by material impulses ... merchants stood as a driving force behind the heroes of the age of discovery; this first heroic impulse to conquer the world emanated from very mortal forces—in the beginning, there was spice.”
—Stefan Zweig (18811942)
“The modern world needs people with a complex identity who are intellectually autonomous and prepared to cope with uncertainty; who are able to tolerate ambiguity and not be driven by fear into a rigid, single-solution approach to problems, who are rational, foresightful and who look for facts; who can draw inferences and can control their behavior in the light of foreseen consequences, who are altruistic and enjoy doing for others, and who understand social forces and trends.”
—Robert Havighurst (20th century)
“The evolution of humans can not only be seen as the grand total of their wars, it is also defined by the evolution of the human mind and the development of the human consciousness.”
—Friedrich Dürrenmatt (1921–1990)