- Marilyn Manson
- Marilyn Manson – arp, bass, composer, drums (electric, syncussion), guitar (rhythm), photography, piano, production, synthesizer, vocals (lead, background), vocoder
- Ginger Fish – drums (live, electric), vocals, vocoder
- Twiggy Ramirez – bass guitar, composer, guitar (electric, acoustic, rhythm), noise, clavinet
- M.W. Gacy - composer, drums, drums (electric), keyboards, Mellotron, piano, sampling, shaker, synthesizer
- John 5 - live guitarist for Mechanical Animals
- Zim Zum - composer, guitar (electric, acoustic, rhythm, synthesizer, "pitifully predictable guitar solo"), keyboards
- Additional musicians
- Dave Navarro - guitar on "I Don't Like the Drugs (But the Drugs Like Me)"
- Danny Saber – keyboards, clavinet, strings, programming
- Rose McGowan - vocals on "Posthuman"
- Alexandra Brown - background vocals on "I Don't Like the Drugs (But the Drugs Like Me)"
- Lynn Davis - background vocals on "I Don't Like the Drugs (But the Drugs Like Me)"
- Dyanna Lauren - "pornography" on "New Model No.15"
- John West - background vocals on "I Don't Like the Drugs (But the Drugs Like Me)"
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- Production and personnel
- Sean Beavan - production, engineering, programming, digital editing
- Barry Goldberg - engineering
- Tom Lord-Alge – mixing
- Joseph Cultice – photography
- Michael Beinhorn - production
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