Mary Talbot may refer to:
- Mary Talbot, Countess of Northumberland, courtier who married Anne Boleyn's former suitor, Henry Percy
- Mary Talbot, Countess of Shrewsbury (1556-1632), daughter of Bess of Hardwick
- Mary Talbot Herbert, Countess of Pembroke, (c. 1594-1649), daughter of the above
- Mary Anne Talbot (1778-1808)
- Mary M. Talbot, scholar and author of Dotter of Her Father's Eyes
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