Commendations
- In 1994, Skankin' Pickle released their album Sing Along With Skankin' Pickle featuring a song entitled "It's Margaret Cho."
- In 1999, I'm The One That I Want won New York magazine's Performance of the Year award and was named one of the Great Performances of the year by Entertainment Weekly.
- In 2000, her "E! Celebrity Profile" won a Gracie Allen Award from the American Women in Radio and Television organization acknowledging its "superior quality and effective portrayal of the changing roles and concerns of women."
- In 2000, the Gay & Lesbian Alliance Against Defamation (GLAAD) awarded her with a Golden Gate award and described her as an entertainer who, "as a pioneer, has made a significant difference in promoting equal rights for all, regardless of sexual orientation or gender identity."
- In 2001, she was given a Lambda Liberty Award by Lambda Legal for "pressing us to see how false constructions of race, sexuality, and gender operate similarly to obscure and demean identity."
- In 2003, she received a "Justice in Action" award from the Asian American Legal Defense and Education Fund.
- In 2003, she was given an Intrepid Award by the National Organization for Women.
- In 2004, she was awarded with the First Amendment Award from the American Civil Liberties Union.
- In 2007, she won for Outstanding Comedy Performance in AZN's Asian Excellence Awards.
- April 30, 2008 was declared "Margaret Cho Day" in San Francisco, CA.
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