Lysozyme

Identifiers Symbols LYZ; LZM External IDs OMIM: 153450 MGI: 96897 HomoloGene: 121490 GeneCards: LYZ Gene EC number 3.2.1.17

Gene Ontology
Molecular function	• lysozyme activity
Cellular component	• extracellular region • extracellular space
Biological process	• inflammatory response • cell wall macromolecule catabolic process • cytolysis • defense response to bacterium
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4069 17105 Ensembl ENSG00000090382 ENSMUSG00000069516 UniProt P61626 Q3TXG2 RefSeq (mRNA) NM_000239.2 NM_017372 RefSeq (protein) NP_000230.1 NP_059068 Location (UCSC) Chr 12:
69.74 – 69.75 Mb Chr 10:
116.68 – 116.69 Mb PubMed search

Lysozymes, also known as muramidase or N-acetylmuramide glycanhydrolase, are glycoside hydrolases, enzymes (EC 3.2.1.17) that damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is abundant in a number of secretions, such as tears, saliva, human milk, and mucus. It is also present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN). Large amounts of lysozyme can be found in egg white. C-type lysozymes are closely related to alpha-lactalbumin in sequence and structure, making them part of the same family.