Local Anesthetics in Clinical Use
Esters are prone to producing allergic reactions, which may necessitate the use of an Amide. The names of each locally clinical anesthetic have the suffix "-caine". In general Amides have two "i"'s in their nomenclature while the Esters only have one.
Most ester local anesthetics are metabolized by pseudocholinesterases, while amide local anesthetics are metabolized in the liver. This can be a factor in choosing an agent in patients with liver failure.
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—State of New Mexico, U.S. public relief program (1935-1943)