2000
- explodingdog by Sam Brown (January 9, 2000 – ..)
- The Beevnicks by Owen Dunne (January 16, 2000 – ..)
- Sinfest by Tatsuya Ishida (January 17, 2000 – ..)
- Greystone Inn by Brad Guigar (February 14, 2000 – May 28, 2005)
- Bob and George, the Comic by David Anez (April 1, 2000 – July 28, 2007)
- Diesel Sweeties by Richard Stevens (April 2000 – ..)
- Lethargic Lad by Greg Hyland (Print: 1991 – .., Web: April 2000 – ..)
- Schlock Mercenary by Howard Tayler (June 12, 2000 – ..)
- Exploitation Now by Michael Poe (7 July 2000 – August 26, 2002)
- GU Comics by Woody Hearn (July 10, 2000 – ..)
- Chopping Block by Lee Adam Herold (July 25, 2000 – May 5, 2009)
- Narbonic by Shaenon K. Garrity (July 31, 2000 – December 31, 2006)
- The Joy of Tech by Liza Schmalcel and Bruce Evans (August 14, 2000 – ..)
- Megatokyo by Fred Gallagher and Rodney Caston (August 14, 2000 – ..)
- RPG World by Ian J (August 27, 2000 – September 15, 2008)
- Angst Technology by Barry Smith (August 28, 2000 – June 20, 2005)
- Unicorn Jelly by Jennifer Diane Reitz (September 5, 2000 – April 14, 2003)
- The Pain – When Will It End? by Tim Kreider (September 20, 2000 – June 8, 2009)
- Sosiaalisesti rajoittuneet (Socially Challenged) by Pekka Piira, Ossi Mäntylahti and Jukka Piira (October 20, 2000 - ..)
- Mac Hall by Ian McConville and Matt Boyd (November 7, 2000 – September 22, 2006)
- Checkerboard Nightmare by Kristofer Straub (November 10, 2000 – ..)
- Little Gamers by Christian Fundin and Pontus Madsen (December 1, 2000 – ..)
- Dork Tower by John Kovalic (January 1997 (web appearance: 2000) – ..)
Read more about this topic: List Of Webcomics