Guiding Light
- Michelle Bauer Santos
- played by Anna Tendler (1985–1988); Rachel Miner (1989–1995); Rebecca Budig (1995–1998); Bethany Joy Lenz (1998–2000); Nancy St. Alban (2000–2005, 2009).
- Annie Dutton
- played by Cynthia Watros (1994–1998); Signy Coleman (1998–1999, 2003)
- Blake Thorpe Marler
- played by Gina Foy (1975-1978); Cheryl Lynn Brown (1979-1980); Elizabeth Dennehy (1988–1989); Sherry Stringfield (1989–1992); Elizabeth Keifer (1992–2009)
- Dinah Marler
- played by Jennifer Gatti (1986–1987); Paige Turco (1987–1989); Wendy Moniz (1995–1999); Gina Tognoni (2004–2009)
- Beth Raines
- played by Judi Evans Luciano (1983–1986); Beth Chamberlin (1989–1991, 1997–2009)
- Alan-Michael Spaulding
- played by Carl T. Evans (1987–1990); Rick Hearst (1990–1996); Michael Dietz (1996–1997); Michael Dempsey (2005–2007)
- Lizzie Spaulding
- played by Hayden Panettiere (1997–2000); MacKenzie Mauzy (2000–2002); Allison Hirschlag (2002–2003); Crystal Hunt (2003–2006); Marcy Rylan (2006–2009)
- Cassie Layne Winslow
- played by Laura Wright (1997–2005); Nicole Forester (2005–2008)
- Viola Stapleton
- played by Sudie Bond (1976); Kate Wilkinson (1976–1981)
- Barbara Thorpe
- played by Augusta Dabney (1970–1971); Barbara Berjer (1971–1981)
- Sara McIntyre
- played by Patricia Roe 1967 - 1968; Jill Andre 1968; Millette Alexander 1969 - 1982
- Charlotte Waring
- played by Victoria Wyndham 1967 - 1969; Felice Camargo 1969 - 1973
- Alan Spaulding
- played by Christopher Bernau 1977 - 1984, 1986 - 1988; Daniel Pilon 1988 - 1989; Ron Raines 1994–2009
- Meta Bauer
- played by Ellen Demming 1953 - 1974; Mary Stuart 1996 - 2002
- A.C. Mallet
- played by Mark Derwin (1990–1993); Robert Bogue (2005–2009)
- Eleni Andros Cooper
- played by Melina Kanakaredes (1991–1995); Jennifer Roszell (1995–2000, 2001–2002)
- Marina Cooper
- played by Aubrey Dollar (2001–2004); Mandy Bruno (2004–2009)
- Marah Lewis
- played by Ashley Peldon (1989–1991); Kimberly J. Brown (1993–1998, 2006); Lauren C. Mayhew (1998–1999); Laura Bell Bundy (1999–2001); Lindsey McKeon (2001–2004)
- Bill Lewis III
- played by Bryan Buffington (1989–1998); Ryan Brown (1998–2001); Daniel Cosgrove (2002–2005; 2007–2009)
Read more about this topic: List Of Soap Opera Recasts