General Hospital
- Sage Alcazar
- played by Eileen Boylan (2003); Katie Stuart (2003–2004)
- Brook Lynn Ashton
- played by Brooke Radding (1999–2001); Adrianne Leon (2004–2006, 2010–2011)
- Ned Ashton
- played by Kurt McKinney (1988–1991); Wally Kurth (1991–2005, 2006, 2007)
- Christina Baldwin
- played by Angela and Michelle Mora (1999–2000); Kaitlyn Maggio (2001–2003)
- Scott Baldwin
- played by Johnny Whitaker (1965); Kin Shriner (1977–1983, 1987–1993, 2001–2004, 2007–2008)
- Thomas Baldwin Sr.
- played by Paul Savior (1967–1972); Don Chastain (1977–1982, 1984–1987); David Walker (1982–1984)
- Carly Benson
- played by Sarah Brown (1996–2001); Tamara Braun (2001–2005); Jennifer Bransford (2005); Laura Wright (2005—present)
- Meg Bentley Baldwin
- played by Patricia Breslin (1966–1969); Elizabeth MacRae (1969–1970, 1972–1973)
- Brooke Bentley Clinton
- played by Adrienne Hayes (1965–1968); Indus Arthur (1970–1973)
- Gia Campbell
- played by Marisa Ramirez (2000–2002); Andrea Pearson (2002–2003)
- Tammy Carson
- played by Patricia Healy (1998–2000); Tamara Clatterbuck (2000–2001)
- Helena Cassadine
- played by Elizabeth Taylor (1981); Dimitra Arliss (1996); Constance Towers (1997–2002, 2003, 2004–2007, 2009, 2010, 2011)
- Nikolas Cassadine
- played by Tyler Christopher (1996–1999, 2003–2011); Stephen Martines (1999–2003); Chris Beetem (2005)
- Spencer Cassadine
- played by Nathan and Spencer Casamassima (2006–2007); Lance Doven (2008); Rami Yousef (2009); Davin Ransom (2009–2011)
- Stavros Cassadine
- played by John Martinuzzi (1983); Robert Kelker-Kelly (2001, 2002, 2003)
- Gina Cates
- played by Nikki Cox (1993–1995); Gina Gallagher (1996); Stephanie Dicker (1996–1997)
- Lois Cerullo
- played by Rena Sofer (1994–1996, 1997); Lesli Kay (2004–2005)
- Michael Corinthos
- played by Dylan and Blake Hopkins (1997–2001); Tiernan Cunningham (2001–2002); Dylan Cash (2002–2008); Drew Garrett (2009–2010); Chad Duell(2010—)
- Morgan Corinthos
- played by Jake Simms (2005); George Juarez (2005–2009); Aaron Refvem (2009–2010); Aaron Samders (2010—)
- Gina Dante-Lansing
- played by Anna Stuart (1977–1978); Brenda Scott (1978); Donna Baccala (1978–1979)
- Kristina Davis
- played by Sarah and Emma Smith (2003–2005); Kali Rodriguez (2005–2009); Lexi Ainsworth (2009–2011); Lindsey Morgan (2012–present)
- Anna Devane
- played by Finola Hughes (1985–1991, 1995, 2006, 2007, 2008); Camilla Moore (1991–1992)
- Roy DiLucca
- played by Asher Brauner (1978–1979); A Martinez (1999–2002)
- Pierce Dorman
- played by Bradley White (1996); Rob Youngblood (1996); Tuc Watkins (1996–1997)
- Tom Hardy Snr
- played by Christine Cahill (1971–1974); David Comfort (1977–1981); Bradley Green (1981–1982); David Wallace (1987–1989, 1993); Matthew Ashford (1995–1997)
- Kate Howard
- played by Megan Ward (2007–2010); Kelly Sullivan (2011—present)
- Jerry Jacks
- played by Julian Stone (1998–1999); Sebastian Roche (2007–2008, 2009, 2010)
- Stan Johnson
- played by Gomez Warren (2003–2006); Karim Prince (2006–2007); Kiko Ellsworth (2007)
- Frisco Jones
- played by Jack Wagner (1983–1988, 1989–1991, 1994, 1995); Kevin Bernhardt (1985)
- Maxie Jones
- played by Robyn Richards (1993–2004); Danica Stewart (2002); Kirsten Storms (2005–2011); Jen Lilley (2011—2012)
- A. J. Quartermaine
- played by Sean Kanan (1993–1997); Billy Warlock (1997–2003, 2005)
- Edward Quartermaine
- played by David Lewis (1978–1993); John Ingle (1993–2004, 2006—); Jed Allan (2004–2006)
- Monica Quartermaine
- played by Patsy Rahn (1976); Leslie Charleson (1977—)
- Emily Bowen-Quartermaine
- played by Amber Tamblyn (1995–2001); Natalia Livingston (2003–2008)
- Felicia Scorpio-Jones
- played by Kristina Wagner (1984–2003, 2004–2005, 2007–2008); Sandra Ferguson (2005)
- Lucky Spencer
- played by Jonathan Jackson (1993–1999, 2009–2011); Jacob Young (2000–2003); Greg Vaughan (2003–2009)
- Dominique Stanton
- played by Tawny Fere Ellis (1991); Shell Danielson (1992–1993)
- Justus Ward
- played by Joseph C. Phillips (1994–1998); Monti Sharp (1998–1999); M'fundo Morrison (2003–2006)
- Steven Webber
- played by Martin Hewitt (1979); Shaun Benson (2004–2005); Scott Reeves (2009—)
Read more about this topic: List Of Soap Opera Recasts