S
- Jeffrey D. Sadow (born 1962) political scientist, columnist, educator
- Larry G. Sale (1893-1977), sheriff; Huey P. Long bodyguard
- Joe R. Salter (born 1943) politician, educator
- Joe Sampite (1931-2012) politician
- J. Berry Sandefur (1868–1954) politician
- Jean Oliver Sartor (1918-2007) artist
- Kurtis Scaletta writer
- Tom Schedler (born 1950) politician, businessman
- Clay Schexnayder (born 1969) politician, businessman
- Fred L. Schiele (1933–2002) state representative and sheriff of Concordia Parish
- Matthew P. "Pete" Schneider, III (born 1953) politician, businessman
- John Schroder (born 1966) politician, businessman
- John F. Schwegmann (born 1946) politician, businessman
- John G. Schwegmann (1911–1995) politician businessman
- Melinda Schwegmann (born 1947) lieutenant governor from 1992 to 1996
- Mike Scifres (born 1980) punter for the San Diego Chargers
- Ed Scogin (1921–1999) state representative from St. Tammany Parish (1972–1992)
- Jock Scott (1947–2009) politician, historian, lawyer
- Nauman Scott (1916–2001) judge
- W. Ray Scott (1923–2008) mayor of Natchitoches (1960–1976)
- Pat Screen (1943–1994) Mayor-President of East Baton Rouge Parish (1981–1988)
- Alan Seabaugh (born ca. 1967) state representative
- J.C. Seaman (1898–1964) state representative from Tensas Parish (1944–1964)
- Andrew L. Sevier (1894–1962) politician
- Rob Shadoin (born 1953) politician
- George W. Shannon (1914–1998) newspaper editor
- Amanda Shaw (born 1990) actress, singer and fiddler
- B.L. "Buddy" Shaw (born 1933) politician and educator
- Rhonda Shear (born 1954) beauty queen, television host
- Ben Sheets (born 1978) starting pitcher for the Oakland A's
- Virginia Shehee (born 1923) businesswoman, first woman to serve in Louisiana State Senate (1976–1980)
- Eddy Shell (1937–2008) educator; politician
- Clarence Shelmon (born 1952) offensive coordinator for the San Diego Chargers
- Kenny Wayne Shepherd (born 1977) musician
- Lawrence A. Sheridan (1919–2001) state representative
- Chris Shivers (born 1978) professional bull rider
- Jimmy G. Shoalmire (1940–1982), historian
- Don Shows (born 1940), football coach
- Henry Miller Shreve (1785–1854) inventor, steamboat captain
- Phil Short (born 1947) state senator; relocated to Virginia
- Rockin' Sidney (1938–1998) Zydeco star
- Richard Simmons (born 1948) entertainer
- Scott M. Simon state representative
- Bobby R. Simpson (born 1953) politician
- Oramel H. Simpson (1870–1932) Governor of Louisiana (1926–1928
- Dale Sittig (born 1941) politician
- Fulwar Skipwith (1765–1839) diplomat, politician
- Eric Skrmetta (born 1958) politician
- John Slidell (1793–1871) U.S. Senator, Confederate diplomat
- Soulja Slim (1977–2003) musician
- Donald Sloan (born 1988) guard for the Atlanta Hawks
- Floyd W. Smith, Jr. (1932–2010) politician
- Howard K. Smith (1914–2002) journalist, reporter
- James Monroe Smith (1888–1949) president of Louisiana State University in 1930s
- Jane H. Smith (born 1948) first woman high school principal, school superintendent, and state legislator from Bossier Parish
- Joe D. Smith, Jr. (1922–2008) newspaper publisher, businessman
- John R. Smith (born 1945) politician
- Kenneth Michael "Mike" Smith (born 1948), politician, businessman
- Otis Smith (born 1965) former New England Patriots cornerback, Kansas City Chiefs assistant coach
- P.K. Smith (1917–1983) state representative, Winnfield businessman
- Ada Jack Carver Snell (1890–1972) short story writer
- David Snell (1921–1987) journalist and cartoonist for Life Magazine
- John K. Snyder (1922–1993) mayor of Alexandria (1973–1977; 1982–1986)
- Robert C. Snyder (1919–2011) professor of English at Louisiana Tech University
- Robert H. Snyder (died 1906) politician
- Steven Soderbergh (born 1963), film producer, screenwriter, cinematographer, film director
- Floyd Soileau (born 1938) record producer
- Ian Somerhalder (born 1978) actor, model
- Art Sour (1924–2000) State Representative from Shreveport, 1972–1992
- Britney Spears (born 1981) singer
- Jamie Lynn Spears (born 1991) actress
- Marcus Spears (born 1983), defensive end for the Dallas Cowboys
- Freddie Spencer (born 1961) world motorcycle champion
- Tommy Spinks (1948–2007) football player
- Tam Spiva (born 1932) Hollywood script writer
- Tom Stagg (born 1923) U.S. District Court judge
- Edward J. Steimel (born 1922) founder of Louisiana Association of Business and Industry
- Victor T. "Vic" Stelly (born 1941) politician
- Craig Steltz (born 1986) safety for the Chicago Bears
- Jason Stern (born 1977) politician, activist, musician, photographer
- Kordell Stewart (born 1972) NFL quarterback/wide receiver
- Brandon Stokley (born 1976) wide receiver for the Seattle Seahawks
- Jesse N. Stone (1924–2001) civil rights activist; Southern University System president, 1974–1985
- Carl Stracener (1931-2011) physician and inventor
- Michael G. Strain (born 1959) veterinarian; former state representative; Louisiana commissioner of Agriculture and Forestry
- Roy C. Strickland (1942–2010) businessman; politician
- Patrick Surtain (born 1976) NFL cornerback
- Hal Sutton (born 1958) PGA Tour golfer
- Liz Swaine (born 1960) broadcast journalist
- Jimmy Swaggart (born 1935) evangelist
- Marc Swayze (1913-2012) comic book writer and illustrator
- Lawson Swearingen (born 1944) former state senator from Ouachita Parish and later the president of the University of Louisiana at Monroe
- Stephanie Swift (born 1972) actress
- Stromile Swift (born 1979) NBA player, Memphis Grizzlies
- Harold Sylvester (born 1949) actor, Married... with Children, Today's F.B.I., Shaky Ground
Read more about this topic: List Of People From Louisiana