M
- Sherman Q. Mack (born 1972) politician
- Anthony Mackie (born 1979) actor, Eagle Eye, Million Dollar Baby
- Magic Sam (1937–1969) blues music pioneer
- Karl Malone (born 1963) former basketball great, mainly with the Utah Jazz
- Max T. Malone (born 1953) geologist and state senator
- Jeff Mangum (born 1970) musician, founder of Neutral Milk Hotel
- Archie Manning (born 1949) former New Orleans Saints quarterback
- Eli Manning (born 1982) New York Giants quarterback
- Peyton Manning (born 1976) Indianapolis Colts quarterback
- Tommy Manzella (born 1983) shortstop for the Houston Astros
- Charles E. Maple (1932–2006) journalist
- "Pistol" Pete Maravich (1947–1988) LSU & NBA basketball Hall of Famer
- Paul Mares (1900–1949) musician
- Anna Margaret (born 1996), singer
- Angélica María (born 1944), Mexican actress and singer
- Robert M. Marionneaux (born 1968), politician
- Branford Marsalis (born 1960) musician
- Ellis Marsalis, Jr., (born 1934) musician, educator
- Ellis Marsalis, Sr., (c. 1908–2004) poultry farmer, jazz musician, hotelier, civil rights activist
- Wynton Marsalis (born 1961) musician
- Leonard Marshall (born 1961) former defensive end, primarily for the New York Giants
- Wade O. Martin, Jr. (1911–1990) secretary of state
- Wade O. Martin, Sr. (1885–1956) politician
- Danny Martiny (born 1951) politician
- Virginia Martinez (1922–1992) Louisiana Republican national committeewoman from 1977 until her death
- Enos C. McClendon, Jr. (1917-2003) judge
- Charles E. McConnell (1923-2000) politician
- Billy McCormack (1928-2012) Baptist pastor, director and vice president of the Christian Coalition of America
- James L. McCorkle, Jr. (born 1935) historian
- Jim McCrery (born 1949) former US Representative
- Tim McGraw (born 1967) country musician, actor
- Tom Ed McHugh (born 1943) politician
- J. Frank McInnis (1886–1959) judge
- John McKeithen (1918–1999) Governor of Louisiana from 1964 to 1972
- W. Fox McKeithen (1946–2005) Louisiana secretary of state, 1988–2005
- Charles E. McKenzie (1896-1956) U.S. representative
- Joe McKnight (born 1988) tailback for the New York Jets
- Chuck McMains (born 1948) former state representative and Baton Rouge lobbyist
- Joe McPherson (born 1950) state senator from Rapides Parish
- Tom McVea (born 1945) state representative
- Gil Meche (born 1978) former MLB pitcher
- D.L. Menard (????) Cajun musician from Erath
- Adah Isaacs Menken (1835–1868) actress
- Louis J. Michot (born 1922), businessman, former state superintendent of education, and State Representative from Lafayette
- Michael J. Michot (born 1963), businessman, state senator from Lafayette since 2000
- Quintin Mikell (born 1980), safety for the Philadelphia Eagles
- Roderick Miller (1924–2005) politician, lawyer
- Fred H. Mills, Jr. (born 1955) politician, pharmacist, banker
- Newt V. Mills (1899-1996) U.S. representative
- P.J. Mills (born 1934) politician, businessman
- Paul Millsap (born 1985) power forward for the Utah Jazz
- Lizzie Miles (1895–1963) singer
- Percy "Master P" Miller (born 1967) musician, actor, record producer, athlete
- Alexander Milne (1742–1838) businessman, slave-trader, philanthropist
- Leland G. Mims (1901–1979) politician
- E. R. Minchew (1908–2001) educator
- RJ Mitte (born 1992) actor, Walt, Jr. on Breaking Bad
- Randy Moffett (born 1947) educator
- Robert W. Mondy (1908–1997) historian
- Nickie Monica (born 1960) politician
- Bill Monroe (1920–2011) journalist, host of Meet the Press (1975–1984)
- Greg Monroe (born 1990) center for the Detroit Pistons
- Billy Montgomery (born 1937) politician and former educator
- Harold Montgomery (1911–1995) state senator and businessman
- John Willard "Jack" Montgomery, Sr. (born 1936) state senator and lawyer
- Little Brother Montgomery (c. 1906–1985) musician
- Cleo Moore (1923–1973) 1950s movie star
- Danny Roy Moore (born 1925) state senator from Claiborne Parish, 1964–1968
- Ellen Bryan Moore (1912–1999) former Register of State Lands, captain in Women's Army Corps during World War II
- Mewelde Moore (born 1982) running back for the Pittsburgh Steelers
- W. Henson Moore (born 1939) former US Representative
- Jackie Moreland (1938–1971) professional basketball player
- Aaron Morgan (born 1988), outside linebacker and defensive end for the Jacksonville Jaguars
- Cecil Morgan (1898–1999) state legislator who led the impeachment forces against Huey Pierce Long, Jr., later executive with Standard Oil Company and dean of Tulane University Law School
- Elemore Morgan, Jr. (1931–2008) landscape painter and photographer
- Lewis L. Morgan (1876-1950) U.S. representative; 1944 gubernatorial runoff candidate
- Dutch Morial (1929–1989) judge, mayor of New Orleans
- Jay Morris (born 1958), state representative from Ouachita and Morehouse parishes
- James Hollis "Jim" Morris (born 1954), state representative from Caddo and Bossier parishes
- Dan Morrish (born 1950), member of both houses of the Louisiana State Legislature
- deLesseps Story Morrison (1912–1964), mayor of New Orleans, ambassador to the Organization of American States, three-time gubernatorial candidate
- Jacob Haight Morrison (1905–1974), politician, historical preservationist
- James H. Morrison (1908–2000) US Representative
- Jelly Roll Morton (1890–1941) musician, composer, self-proclaimed "inventor of jazz"
- Morgus the Magnificent (born ????) horror host
- Paul Morphy (1837–1884) world chess champion
- Garrett Morris (born 1937) comedian, Saturday Night Live
- Isaac Edward Morse (1809–1866) Louisiana state Attorney General and US Congressman
- Alexander Mouton (1804–1885) Governor and United States Senator
- Ashton J. Mouton (1916–1988) mayor of Lafayette
- Jonas Mouton (born 1988) linebacker for the San Diego Chargers
- George B. Mowad (1932–2000) mayor of Oakdale, physician, developer
- Bernhard Müller (1788–1834) colonizer of Grand Ecore in Natchitoches Parish
- W. Spencer Myrick (1913–2001) state legislator from West Carroll Parish
Read more about this topic: List Of People From Louisiana