L
- Adras LaBorde (1912–1993) journalist
- Raymond Laborde (born 1927) politician
- John LaBruzzo (born 1970) politician
- Len Lacy (1900–1998) politician
- Alvan Lafargue (1883–1962) physician and politician
- Ed Lafitte (1886–1971) baseball player
- Jean Lafitte (c. 1780 – c. 1826) blacksmith, pirate
- Papa Jack Laine (1873–1966) bandleader
- Eddie J. Lambert (born 1956) state representative
- Louis Lambert (born 1940) politician
- Dorothy Lamour (1914–1996) actress
- Katherine LaNasa (born 1966) actress, Judging Amy
- Mary Landrieu (born 1955) US Senator
- Mitch Landrieu (born 1960) politician
- Moon Landrieu (born 1930) judge, politician
- Ali Landry (born 1973) actress, model, Miss USA 1996
- Jeff Landry (born 1970) politician
- Lisa Landry (born 1977) stand-up comedian
- Nancy Landry (born 1962) politician
- Eric Laneuville (born 1952), actor, TV director, St. Elsewhere, Room 222
- Carroll E. Lanier (born 1927) mayor of Alexandria from 1977 to 1982
- Nick LaRocca (1889–1961) self-proclaimed "inventor of jazz"
- John Larroquette (born 1947) actor
- Dud Lastrapes (born 1929) mayor of Lafayette from 1980 to 1992
- Hank Lauricella (born 1930) football player; state senator
- Marie Laveau (c. 1794 – c. 1881) Voodoo priestess
- Samuel Lawrason (1852–1924) - state senator who authored Lawrason Act regarding Louisiana municipal government
- Claude "Buddy" Leach (born 1934) politician, businessman
- Leadbelly (1885–1949) musician
- Dudley J. LeBlanc (1894–1971) politician, businessman who made a fortune in the patent medicine Hadacol
- Fred S. LeBlanc politician
- Patrick LeBlanc (1954–2008) architect, businessman, politician
- Marietta LeBreton (1936–2009) historian
- Richard Leche (1898–1965) Governor of Louisiana
- David Lee (born 1943) football player
- Harry Lee (1932–2007) Jefferson Parish sheriff
- John A. Lejeune (1867–1942), Marine Corps general
- Lloyd E. Lenard (1922–2008), politician, businessman, author
- Art Lentini (born 1953), former state senator
- Countess Leon (1798–1881), founder of Germantown Colony in Webster Parish
- Elmore Leonard (born 1925) author
- Joe LeSage (born 1928), former state senator and LSU supervisor
- Jared Leto (born 1971) actor, lead singer/guitarist of alternative rock band 30 Seconds to Mars
- Shannon Leto (born 1970) drummer of alternative rock band 30 Seconds to Mars, occasional actor
- Zachary Levi (born 1980) actor, Less than Perfect, Chuck
- Jerry Lee Lewis (born 1935) musician
- Keenan Lewis (born 1986), cornerback for the Pittsburgh Steelers
- Michael Lewis (born 1960), author, financial journalist
- Rashard Lewis (born 1979), forward for the Orlando Magic
- Tony Ligi (born ca. 1955), politician
- Lil' Wayne (D'Wayne Michael Carter) Rapper
- Coleman Lindsey (1892–1968) politician
- F.A. Little, Jr. (born 1936), retired judge of the United States District Court for the Western District of Louisiana
- Sam Little (born 1950) politician
- Lloyd Harlin Polite (born 1986) R&B singer
- Nate Livings (born 1982) guard for the Dallas Cowboys
- Bob Livingston (born 1943) congressman (1977–1999)
- Edward Livingston (1764–1836) congressman, United States Secretary of State
- Lloyd (born 1986), R&B and hip hop artist
- Blanche Long (1902–1998), Mrs. Earl Long, First Lady of Louisiana, 1939–1940; 1948–1954; 1956–1960
- Earl Kemp Long (1895–1960) Governor of Louisiana (1939–1940, 1948–1952, and 1956–1960)
- George S. Long (1883–1958) US Representative
- Gerald Long (born 1944), Republican state senator from Natchitoches; only elected Republican official of Long family
- Gillis William Long (1923–1985), US Representative
- Huey Pierce Long, Jr., (1893–1935) former Governor of Louisiana, US Senator
- Jimmy D. Long (born 1931) politician
- Russell Long (1918–2003) US Senator
- Speedy O. Long (1928–2006) US Representative and district attorney from La Salle Parish
- Professor Longhair (1918–1980) musician
- Joseph Lopinto (born ca. 1976) state representative from Jefferson Parish
- Nicholas Lorusso (born 1966) state representative from Orleans Parish since 2007
- W. Matt Lowe (1872–1955) politician
- Walter M. Lowrey (1921–1980) historian
- Charlton Lyons (1894–1973) "father of modern Republican Party in Louisiana"
- Ted Lyons (1900–1986) Hall of Fame baseball player
Read more about this topic: List Of People From Louisiana