D
- Casey Daigle (born 1981) relief pitcher for the San Francisco Giants
- Jay Dardenne (born 1954) state senator, Louisiana secretary of state, and lieutenant governor since 2010
- John T. David (1897–1974) politician
- Buster Davis (born 1985) wide receiver for the San Diego Chargers
- Glen Davis (born 1986) power forward and center for the Orlando Magic
- Jackson B. Davis (born 1918) attorney and former state senator
- Jimmie Davis (1899–2000) singer, Governor of Louisiana
- Paul M. Davis, Jr. (1919-2007) orthopedic surgeon and medical author
- Willie Davis (born 1934) Hall of Fame defensive end for the Cleveland Browns and Green Bay Packers
- Keyunta Dawson (born 1985) defensive end for the Indianapolis Colts
- Nelder Dawson (1928–2006) newspaper executive
- Lynn Dean (born 1923) politician
- Pap Dean (born 1915) cartoonist
- Cleveland Dear (1888-1950) politician
- Michael E. DeBakey (born 1908) pioneering cardiovascular surgeon
- Edmond Dede (1827–1903) musician, composer
- J.D. DeBlieux (1912–2005) state senator
- Robert DeBlieux (1933–2010) historic preservationist and mayor of Natchitoches from 1976 to 1980
- Ellen DeGeneres (born 1958) actress, comedian
- Charles deGravelles (1913–2008) Republican politician and businessman from Lafayette
- Virginia deGravelles (born 1915) former Republican national committeewoman
- Jake Delhomme (born 1975) quarterback for the Houston Texans
- David Dellucci (born 1973) retired MLB outfielder, played primarily with the Arizona Diamondbacks
- Vail M. Delony (1901–1967) politician
- James L. Dennis (born 1936) judge of the United States Circuit Court of Appeals for the Fifth Circuit; former judge of the Louisiana Supreme Court; former state representative
- Catherine Dent (born 1965) actress, Danni Sofer on The Shield
- Helen Derr (1918–2011) journalist
- John Desmond (1922–2008) architect
- George Despot (1927–1991) politician and businessman
- Natalie Desselle-Reid (born 1967) actress
- Henry C. Dethloff (born 1934) historian
- Charles W. DeWitt, Jr. (born 1947) politician and rancher
- S. S. DeWitt (1914–1998) politician
- F.O. "Potch" Didier (1919–2007) sheriff
- Margaret Dixon (1908–1970) newspaper editor
- Lurita Doan (born 1958) Administrator of the General Services Administration under President George W. Bush
- William Joseph "Bill" Dodd (1909–1991) politician
- Monroe E. Dodd (1878–1952) Baptist clergyman, educator, and early radio evangelist in Shreveport
- John J. Doles, Jr. (1922–2004) banker
- John J. Doles, Sr. (1895–1970) Plain Dealing banker and state senator from 1952 to 1956
- James R. Domengeaux (1907-1988) U.S. representative; French language cultural activist
- Fats Domino (born 1928) musician
- Jim Donelon (born 1944) politician
- Caroline Dormon (1888–1971) naturalist, horticulturist, promoter of Kisatchie National Forest
- Glenn Dorsey (born 1985) LSU Tigers defensive tackle
- Cat Doucet (1899–1975) sheriff
- Early Doucet (born 1985) wide receiver for the Arizona Cardinals
- Donna Douglas (born 1933) television star, The Beverly Hillbillies
- Emmitt Douglas (1926–1981) president of the Louisiana NAACP from 1966 to 1981
- Gordon Dove (born 1957) state representative; Houma businessman
- Hunt Downer (born 1946) politician; National Guard officer
- Hollis Downs (born 1946) state representative
- Dee D. Drell (born 1947) U.S. district judge in Alexandria
- Harmon Caldwell Drew (1889–1950), district attorney and state district and circuit court judge
- Harmon Drew, Jr. (born 1946), appeals court judge, musician
- R. Harmon Drew, Sr. (1916–1995) city judge, state representative
- Richard Cleveland Drew (1848–1919), state district and circuit court judge
- Richard Maxwell Drew (1822–1850), judge and state representative
- Clyde Drexler (born 1962) former NBA star, Basketball Hall of Fame
- Chris Duhon (born 1982) point guard for the Orlando Magic
- David Duke (born 1950) former state representative, former Ku Klux Klansman
- W.W. Dumas (1916–1993) Mayor-President of East Baton Rouge Parish, 1965–1981
- Charles E. Dunbar (1888–1959), attorney and civil service reformer
- Forrest Dunn (born 1928) politician and museum curator
- Warrick Dunn (born 1975) NFL running back
- Mark Duper (born 1959) Miami Dolphins wide receiver
- Adrian G. Duplantier (1929–2007) U.S. District Judge and former state senator from Orleans Parish
- Jay Duplass (born 1973) film director
- Champion Jack Dupree (c. 1909–1992) boxer, musician
- Chad Durbin (born 1977) Philadelphia Phillies pitcher
- Joey Durel (born 1953) mayor of Lafayette since 2004
- Claude B. Duval (1914–1986) politician
- Stanwood Duval (born 1942) federal judge in New Orleans
- Jack M. Dyer (born ca. 1925) politician
- B.G. Dyess (born 1922) minister and politician
- W.E. "Bill" Dykes (born 1923) politician
Read more about this topic: List Of People From Louisiana