C
- George Washington Cable (1844–1925) writer
- James David Cain (born 1938) politician
- Milburn E. Calhoun (1930-2012) physician, book publisher
- Jefferson Caffery (1886–1974) US ambassador(cousin of Patrick and Donelson Caffery)
- Patrick T. Caffery (1932) US Representative (cousin of Jefferson Caffery and grandson of Donelson Caffery)
- Donelson Caffery (1835–1906) US Senator (grandfather of Patrick T. Caffery)
- Chris Cagle (born 1968) country music artist
- Buddy Caldwell (born 1946) attorney general of Louisiana since 2008
- David T. Caldwell (1925–1993) Shreveport judge
- George A. Caldwell (1892–1966) building contractor; designed twenty-six public buildings in Louisiana
- Sam Caldwell (1892–1953) mayor of Shreveport
- Stephen A. Caldwell (1889–1956) educator
- Meredith Calhoun (1805-ca. 1866) principal founder of Colfax in Grant Parish
- Jorrick Calvin (born 1987) cornerback for the Philadelphia Eagles
- Eugene P. Campbell (c. 1870-1940) sheriff
- Foster Campbell (born 1947) politician
- Theo Cangelosi (1911-1992) politician
- Barney Cannon (1955–2009) Country music deejay
- Billy Cannon (born 1937) LSU Heisman Trophy winner
- Joseph Cao (born 1968) former U.S. representative; lawyer
- Truman Capote (1924–1984) writer
- Lindsey Cardinale (born 1985) American Idol finalist, country singer
- Mark T. Carleton (1935–1995) historian
- Kitty Carlisle (1910–2007) entertainer; married to playwright Moss Hart
- Thomas G. Carmody (born 1961) state representative
- Lane Carson (born 1947) first Vietnam veteran to serve in Louisiana House of Representatives
- Cecil K. Carter, Jr. (born 1927) state senator
- Stephen F. "Steve" Carter (born 1943) state representative
- James Carville (born 1944) political consultant
- Tommy Casanova (born 1950) American football player, ophthalmologist, politician
- Leopold Caspari (1830–1915) politician from Natchitoches
- Bill Cassidy (born 1957) U.S. representative, physician
- John Ardis Cawthon (1907–1984) historian, educator
- Don Cazayoux (born 1964) politician
- Henry E. Chambers (1860–1929) historian, educator
- Simone B. Champagne (born 1954) politician
- Sherri Smith Cheek (born 1966) politician
- Kate Chopin (1851–1904) author
- Ben Claassen III (born 1978) illustrator and comics artist DIRTFARM
- William C. C. Claiborne (1775–1817) first US Governor of Louisiana
- Lewis Strong Clarke (1837–1906) sugar planter and politician
- Ernest S. Clements (1898-1987) politician
- Clifton Chenier (1925–1987) Zydeco musician
- Claire Chennault (1893–1958) aviator, general
- Jack Christian (1911–1972) politician
- Morris Claiborne (born 1990) cornerback for the Dallas Cowboys
- Marcus R. Clark (born 1956) judge
- Ryan Clark (born 1979), safety for the Pittsburgh Steelers
- Patricia Clarkson (born 1959) actress
- Michael Clayton (born 1982), wide receiver for the Tampa Bay Buccaneers
- Ernest Clements (1898–1987) politician
- A.C. "Ace" Clemons, Jr., (1921–1992) first Republican state senator since Reconstruction, switched parties in 1970
- Van Cliburn (born 1934) pianist
- L. L. Clover (1902–1975) clergyman
- Boyer Coe (born 1946) bodybuilder
- Walter L. Cohen (1860–1930) politician and businessman
- J. Frank Colbert (1882–1949) politician
- Frank Estes Cole (1908–1981) politician and educator
- Elliot D. Coleman (1881–1960) sheriff and bodyguard at the assassination of Huey P. Long, Jr.
- Hamilton D. Coleman (1845-1926) U.S. representative from Louisiana's 2nd congressional district, 1889-1991
- Vincent Coleman (1901–1971) actor
- Ashton B. Collier (1910–1973) state representative from Winn Parish
- Marshall Colt (born 1948) actor
- Tom Colten (1922–2004) newspaper publisher and politician
- Amie Comeaux (1976–1997) country singer
- Ward Connerly (born 1939), political activist, businessman, and former University of California Regent
- Harry Connick, Jr., (born 1967) musician, entertainer
- Harry Connick, Sr., (born 1926) district attorney, singer
- Patrick Connick (born 1961) politician
- John Cooksey (born 1941) US Representative
- Joe Henry Cooper (1918–1980) state representative from DeSoto Parish
- Lance Cormier (born 1980) relief pitcher for the Tampa Bay Rays
- Claybrook Cottingham (1881–1949), president Louisiana College and Louisiana Tech University
- Rob Couhig (born 1949) politician, businessman
- Beth Courtney (born 1945) president of Louisiana Public Broadcasting
- Kent Courtney (1918–1997) Radical Right politician
- Carl Crane (born 1939) state representative from Baton Rouge, 1984–2008
- Jack Crichton (1916–2007), Texas oil industrialist and Republican candidate for governor of Texas; native of Red River Parish
- Lane Crockett (born 1942) entertainment journalist from Shreveport
- Greg Cromer (born 1958) state representative from St. Tammany Parish
- Mike Cross (born 1944) politician
- Noah W. Cross (1908–1976) sheriff of Concordia Parish
- Charles Cusimano (born 1954) politician
- Floyd D. Culbertson, Jr. (1908–1989) mayor of Minden from 1940 to 1942
- Ed Cullen (born 1946) journalist and radio essayist
- Allen Ross Culpepper (1944-1969) United States Army captain cited for "extraordinary heroism" in the Vietnam War
- Cupid (born 1982) R&B singer
- Currensy (born 1981) rapper
- Jacob Cutrera (born 1988) middle linebacker for the Jacksonville Jaguars
- Paul N. Cyr (1878–1946) lieutenant governor who quarreled with Huey Pierce Long, Jr.
Read more about this topic: List Of People From Louisiana