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- J. D. Salinger (1919–2010), The Catcher in the Rye
- James Sallis (born 1944), Long-Legged Fly
- James Salter (born 1925), A Sport and a Pastime
- Edgar Saltus (1855–1921), Mr.Incoul's Misadventure
- Lawrence Sanders (1920–1998), The Anderson Tapes
- John Sandford (born 1944), Rules of Prey
- Mari Sandoz (1896–1966), Slogum House
- Colin Sargent (born 1954), Museum of Human Beings
- William Saroyan (1908–1981), The Human Comedy
- May Sarton (1912–1995), Faithful are the Wounds
- John Saul (born 1942), Suffer the Children
- George Saunders (born 1958), The Brief and Frightening Reign of Phil
- John Sayles (born 1950), Pride of the Bimbos
- Jack Schaefer (1907–1991), Shane
- Cathleen Schine (born 1953), Rameau's Niece
- Mark Schorer (1908–1977), A House Too Old
- Budd Schulberg (born 1914), What Makes Sammy Run?
- Christine Schutt (born 19??), All Souls
- Lynne Sharon Schwartz (born 1939), Disturbances in the Field
- Sandra Scoppettone (born 1936), Suzuki Beane
- Evelyn Scott (1893–1963), A Calendar of Sin
- Joanna Scott (born 1960), The Manikin
- Allan Seager (1906–1968), Amos Berry
- Molly Elliot Seawell (1860–1916), The House of Egremont
- Alice Sebold (born 1963), The Lovely Bones
- Catharine Sedgwick (1789–1867), Hope Leslie
- Carolyn See (born 1934), Making History
- Erich Segal (born 1937), Love Story
- Lore Segal (born 1928), Other People's Houses
- Hubert Selby Jr. (1928–2004), Last Exit to Brooklyn
- Anya Seton (1904–1990), Green Darkness
- Mary Lee Settle (1918–2005), Blood Tie
- Michael Shaara (1928–1988), The Killer Angels
- Laurence Shames (born 1951), Florida Straits
- Ntozake Shange (born 1948), Betsey Brown
- Akhil Sharma (born 1971), An Obedient Father
- Irwin Shaw (1913–1984), Rich Man, Poor Man
- Robert Shea (1933–1994), The Illuminatus! Trilogy (with Robert Anton Wilson)
- Wilfrid Sheed (born 1930), Square's Progress
- Sidney Sheldon (born 1917), The Naked Face
- Samuel Shellabarger (1888–1954), Captain from Castile
- Jim Shepard (born 1956), Lights Out in the Reptile House
- Sir Robin Douglass Shepard (pen name) Kohen Ben Gadol (born 1952), Epilogue and Testimony of Kohen Ben Gadol, The Red Letters, The Last Sounding of the Shofar, The Torah, B'reishith,The Complete Book of Genesis, Judeo/Christian Qur'an, The Red Letters, My Isha, Psalms of Praise
- Carol Shields (1935–2003), The Stone Diaries
- Anita Shreve (born 1946), The Weight of Water
- Susan Richards Shreve (born 1939), A Country of Strangers
- Lionel Shriver (born 1957), We Need to Talk About Kevin
- Gary Shteyngart (born 1972), The Russian Debutante's Handbook
- Anne Rivers Siddons (born 1936), Peachtree Road
- Clancy Sigal (born 1926), Going Away
- Leslie Marmon Silko (born 1948), Ceremony
- Robert Silverberg (born 1935), A Time of Changes
- Clifford D. Simak (1904–1988), City
- Dan Simmons (born 1948), Hyperion
- William Gilmore Simms (1806–1870), The Sword and the Distaff
- Mona Simpson (born 1957), Anywhere But Here
- Upton Sinclair (1878–1968), The Jungle
- Isaac Bashevis Singer (1902–1991), Enemies, a Love Story
- Israel Joshua Singer (1893–1944), The Brothers Ashkenazi
- Jane Smiley (born 1949), A Thousand Acres
- Betty Smith (1896–1972), A Tree Grows in Brooklyn
- E. E. Smith (1890–1965), First Lensman
- Elizabeth Oakes Smith (1806–1893), The Western Captive
- Francis Hopkinson Smith (1838–1915), Colonel Carter of Cartersville
- H. Allen Smith (1907–1976), Rhubarb
- Lee Smith (born 1944), Fair and Tender Ladies
- Thorne Smith (1892–1934), Topper
- Zilpha Keatley Snyder (born 1927), The Headless Cupid
- Susan Sontag (1933–2004), In America
- Virginia Sorensen (1912–1991), On This Star
- Christopher Sorrentino (born 1963), Trance
- Gilbert Sorrentino (1929–2006), Mulligan Stew
- Gary Soto (born 1952), Buried Onions
- Terry Southern (1924–1995), The Magic Christian
- E. D. E. N. Southworth (1819–1899), The Hidden Hand
- W. M. Spackman (1905–1980), An Armful of Warm Girl
- Frank H. Spearman (1859–1937), Whispering Smith
- Scott Spencer (born 1945), Endless Love
- Mickey Spillane (1918–2006), I, the Jury
- Norman Spinrad (born 1940), The Iron Dream
- Harriet Elizabeth Prescott Spofford (1835–1921), Sir Rohan's Ghost
- David Derek Stacton (1925–1968), On a Balcony
- Jean Stafford (1915–1979), Boston Adventure
- Jason Starr (born 1966), The Follower
- Danielle Steel (born 1947), Family Album
- Wallace Stegner (1909–1993), Angle of Repose
- Gertrude Stein (1874–1946), The Autobiography of Alice B. Toklas
- John Steinbeck (1902–1968), The Grapes of Wrath
- Darcey Steinke (born 1964), Jesus Saves
- Ann Sophia Stephens (1810–1886), Malaeska: The Indian Wife of the White Hunter
- Neal Stephenson (born 1959), Snow Crash
- Bruce Sterling (born 1954), Islands in the Net
- Richard G. Stern (born 1928), Golk
- Steve Stern, The Angel of Forgetfulness
- Brooke Stevens, Tattoo Girl
- George R. Stewart (1895–1980), Earth Abides
- Frederic Jesup Stimson (1855–1943), The Crime of Henry Vane
- R. L. Stine (born 1943), Monster Blood
- Frank R. Stockton (1834–1902), Rudder Grange
- Mary Stolz (born 1920), The Edge of Next Year
- Grace Zaring Stone (1891–1991), The Bitter Tea of General Yen
- Irving Stone (1903–1989), The Agony and the Ecstasy
- Robert Stone (born 1937), Dog Soldiers
- Phil Stong (1899–1957), State Fair
- Hans Otto Storm (1895–1941), Pity the Tyrant
- Rex Stout (1886–1975), Fer-de-Lance
- Harriet Beecher Stowe (1811–1896), Uncle Tom's Cabin
- Edward Stratemeyer (1862–1930), The Rover Boys At School
- Gene Stratton-Porter (1863–1924), A Girl of the Limberlost
- Peter Straub (born 1943), Ghost Story
- Darin Strauss (born 1970), The Real McCoy
- Edward Streeter (1891–1976), Father of the Bride
- T. S. Stribling (1881–1965), The Store
- Elizabeth Strout (born 1956), Amy and Isabelle
- Jesse Stuart (1906–1984), Taps for Private Tussie
- Theodore Sturgeon (1918–1985), More Than Human
- William Styron (1925–2006), The Confessions of Nat Turner
- Ronald Sukenick (1932–2004), Up
- Cid Ricketts Sumner (1890–1970), Quality
- Jacqueline Susann (1918–1974), Valley of the Dolls
- Harvey Swados (1920–1972), Out Went the Candle
- Glendon Swarthout (1918–1992), The Shootist
Read more about this topic: List Of Novelists From The United States