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- Ralph Sarich (born December 10, 1938) – Invented Orbital engine in 1972 and developed the orbital combustion process engine, which is based on a re-designed two stroke engine using direct gasoline injection
- Thomas Savery (c. 1650 - 1715) - Early steam engine patent holder, author of "A Miner's Friend; or An Engine to Raise Water by Fire"
- Per Georg Scheutz (1785–1873) Pioneer in computer technology (Scheutzian calculation engine)
- Carl Wilhelm Siemens (1823–1883) - Inventor of the regenerative furnace
- Igor Sikorsky (1889–1972) - Aviation engineer, inventor of the single-rotor helicopter, founder of Sikorsky Aircraft Company
- Isaac Singer (1811–1875) - Credited with improvements in lockstitch sewing machine, founder of the Singer Sewing Machine Company
- John Smeaton (1724–1792) - Principally a civil engineer, but made numerous improvements to Newcomen's steam engine
- Edward Somerset (c. 1601-1667) - Numerous mechanical innovations are described in his book "Century of Inventions" published 1663
- Sir William Stanier - Chief Mechanical Engineer of the London, Midland and Scottish Railway.
- George Stephenson (1781–1848) - Known as the "Father of Railways", founder of the Institution of Mechanical Engineers
- Robert Stephenson (1803–1859) - Railway engineer, son of George Stephenson
- Robert Stirling (1790–1878) - Inventor of the Stirling Engine
- Su Song (1020–1101) China - First to use an escapement mechanism (see Yi Xing below) and chain drive to operate his astronomical clock tower
- Dr. Victor Szebehely- Aerospace Engineering & Celestial Mechanics
Read more about this topic: List Of Mechanical Engineers