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- SAGE II / IV CP/M-68K
- SAM Coupé - (Pro-Dos = CP/M 2.2)
- Samsung SPC-1000
- Sanyo MBC families (i.e. MBC-1150)
- SBS 8000
- Scandis
- Seequa Chameleon
- Sharp MZ series
- Sharp X1 series
- Sirius 1 (sold in the U.S. as the Victor 9000)
- Software Publisher's ATR8000
- Sony SMC-70
- Sord CP/M as an option for the 8 bit models, CP/M-68K standard for the M68/M68MX
- Spectravideo SV-318/328
- Stride 400 series CP/M-68K was one of many operating systems on these
- ZX Spectrum +3 (built by Amstrad)
Read more about this topic: List Of Machines Running CP/M