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- Barbara Walters
- Patrick Warburton, explaining "stuck" with a chicken stuck in his shirt
- Malcolm-Jamal Warner
- Naomi Watts, explaining "exchange" with Elmo and Liev Schreiber
- Denzel Washington
- Oprah Winfrey, on season 41 premiere, as the voice of 'O' on "The O Show".
- Lillias White, season 21-24 cast member, 1 street scene: White appeared from 1989 through 1993 as "Lillian", a regular cast member of the show, winning a Daytime Emmy Award for her performance. During her stint, she also voiced the lead singer of The Squirrelles, a Muppet singing group, consisting of three squirrels. She returned in 2006 as a guest for a season 37 street scene, playing Gabi and Miles' kindergarten teacher Ms. Walsh, in a flashback sequence.
- will.i.am
- Brian Williams, demonstrating "squid" in a separately-recorded segment, and also as a guest news-anchor reporting that nobody on Sesame Street is sharing
- Robin Williams, six segments: Williams appeared numerous times in the 1990s and 2000s. In the first, aired in 1992 as episode 2963, Williams uses his shoe to demonstrate what makes something alive. Robin then appeared in a celebrity version of "Monster in the Mirror". Another segment has Robin comparing the similarities and difference between himself and a Muppet robin. In another segment, Williams asks Elmo and the kids whether they would allow a nonsense talking, horned two-headed stranger to play baseball with them. In 2000's episode 3684, Williams talks to Elmo about what you can do with a stick. In 2001's episode 3923, Williams shows off the wonders of feet. The Two Headed Monster shows up to play.
- Vanessa Williams
- Venus Williams
- Joe Williams
- Wendy Williams
- Flip Wilson
- Mookie Wilson
- Chandra Wilson
- Lee Ann Womack
- Stevie Wonder
- B. D. Wong
- Noah Wyle sings with Big Bird
Read more about this topic: List Of Guest Stars On Sesame Street