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- Vlad Shulga Used as a picture on Elmo's house to represent an internet meme.
- Buffy Sainte-Marie
- Adam Sandler sings "a song about Elmo" and meets up with Cookie Monster to talk about the word "crunchy"
- Sharon, Lois & Bram
- Susan Sarandon sings alphabet song
- Diane Sawyer
- Diane Schuur
- Amy Sedaris
- Kyra Sedgwick
- Pete Seeger
- Zoe Saldana defined "Transportation" with Elmo
- David Shiner
- Martin Short
- Paul Simon Sings Me & Julio
- Gene Simmons
- Nina Simone
- The Simpsons
- Eric Singer
- Gene Siskel
- Jeff Smith
- Sonia Sotomayor
- Spin Doctors, one segment, sang the song "Cooperation" (Two Princes) with Elmo, Zoe and Telly Monster
- Squirrel Nut Zippers
- Yeardley Smith (as Lisa Simpson)
- Paul Stanley
- Isaac Stern
- Jon Stewart, defining "practice" in a taped segment
- Patrick Stewart sings alphabet song
- Ben Stiller sang "These are the People in Our Neighborhood" with Telly.
- Michael Stipe
- Ruben Studdard
- Superman
Read more about this topic: List Of Guest Stars On Sesame Street