Lemierre's syndrome (or Lemierre's disease, also known as postanginal sepsis and human necrobacillosis) is a form of thrombophlebitis usually caused by the bacterium Fusobacterium necrophorum, and occasionally by other members of the genus Fusobacterium (F. nucleatum, F. mortiferum and F. varium etc.) and usually affects young, healthy adults. Lemierre's syndrome develops most often after a sore throat caused by some bacterium of the Streptococcus genus has created a peritonsillar abscess, a pocket filled with pus and bacteria near the tonsils. Deep in the abscess, anaerobic bacteria (microbes that do not require oxygen) like Fusobacterium necrophorum can flourish. The bacteria penetrate from the abscess into the neighboring jugular vein in the neck and there they cause an infected clot (thrombosis) to form, from which bacteria are seeded throughout the body by the bloodstream (bacteremia). Pieces of the infected clot break off and travel to the lungs as emboli blocking branches of the pulmonary artery bringing deoxygenated blood from the heart to the lungs. This causes shortness of breath, chest pain and severe pneumonia. Fusobacteria are a normal part of the oropharyngeal flora.
Sepsis following from a throat infection was described by Scottmuller in 1918. However it was André Lemierre, in 1936, who published a series of 20 cases where throat infections were followed by identified anaerobic septicemia, of whom 18 patients died.
Read more about Lemierre's Syndrome: Signs and Symptoms, Cause, Pathophysiology, Diagnosis, Treatment, Prognosis, Epidemiology, History
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