LDL Receptor
| Gene Ontology | |
|---|---|
| Molecular function | • glycoprotein binding • low-density lipoprotein receptor activity • calcium ion binding • protein binding • very-low-density lipoprotein particle receptor activity |
| Cellular component | • lysosome • early endosome • late endosome • Golgi apparatus • plasma membrane • integral to plasma membrane • coated pit • external side of plasma membrane • cell surface • endosome membrane • clathrin-coated endocytic vesicle membrane • low-density lipoprotein particle |
| Biological process | • lipid metabolic process • endocytosis • receptor-mediated endocytosis • cholesterol metabolic process • positive regulation of triglyceride biosynthetic process • regulation of phosphatidylcholine catabolic process • phospholipid transport • virus-host interaction • intestinal cholesterol absorption • cholesterol transport • low-density lipoprotein particle clearance • lipoprotein metabolic process • cholesterol homeostasis • small molecule metabolic process • cholesterol import |
| Sources: Amigo / QuickGO | |
11.2 – 11.24 Mb
21.72 – 21.75 Mb
The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family.
Brown and Goldstein won a Nobel Prize for their identification of the Low Density Lipoprotein (LDL) receptor in 1985 while they were studying familial hypercholesterolemia.
Read more about LDL Receptor: Clinical Significance, Function, Interactive Pathway Map, Mutations
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