Course
Larrys Creek is the only major watershed in Lycoming County entirely within the county. Measured directly, Lycoming County is about 130 miles (210 km) northwest of Philadelphia and 165 miles (266 km) east-northeast of Pittsburgh. It is 53.0 miles (85.3 km) from the mouth of Larrys Creek along the West Branch Susquehanna River to its confluence with the Susquehanna River at Northumberland, Pennsylvania. The source of Larrys Creek is in northern Lycoming County in Cogan House Township, just south of the hamlet of Steam Valley, at an elevation of 1,740 feet (530 m) It flows west-southwest through the village of Cogan House, and then under the Cogan House Covered Bridge.
The creek next heads due south through Pennsylvania State Game Lands Number 114. There it runs for about 3 miles (4.8 km) with only a trail or unimproved road beside it. It passes through Mifflin Township for a short distance and heads southeast into Anthony Township, where it leaves the State Game Lands and passes a water filtration plant; there is a dam 8.5 feet (2.6 m) tall and 52.5 feet (16.0 m) wide here. Further south, it receives Roaring Run (on the left bank). Roaring Run receives the only acid mine drainage in the watershed and enters Larrys Creek 10.4 miles (16.7 km) from the mouth.
Larrys Creek then heads southwest back into Mifflin Township, where it passes through the borough of Salladasburg, with Pennsylvania Route 973 running parallel to the creek from the township line to the borough. At Salladasburg, Larrys Creek receives its major tributary, the Second Fork of Larrys Creek, on the right bank 5.8 miles (9.3 km) from the mouth.
The Second Fork rises in Cogan House Township near the village of White Pine and runs south through the village of Brookside, then a few miles through Cummings Township, and last through Mifflin Township and Salladasburg. Lawshe Run is its major tributary. Pennsylvania Route 287 runs parallel to the Second Fork its whole length, and continues parallel to Larrys Creek from Salladasburg south to its terminus on U.S. Route 220 (near the creek's mouth).
Just south of Salladasburg, Larrys Creek receives the First Fork of Larrys Creek, 4.2 miles (6.8 km) from the mouth. The First Fork has its source in Cummings Township and flows south-southeast into Mifflin Township. 2.8 miles (4.5 km) from its mouth Larrys Creek receives Canoe Run. Both these tributaries enter on the right bank.
Larrys Creek then enters Piatt Township, flowing east around a ridge and through the village of Larryville where it receives Seeley Run on the left bank, 1.5 miles (2.4 km) from the mouth. It next flows back southwest, then south to the hamlet of Larrys Creek and finally into the West Branch Susquehanna River, 2.6 miles (4.2 km) east of the borough of Jersey Shore, at an elevation of 515 feet (157 m). U.S. Route 220 and the Lycoming Valley Railroad cross the creek on separate bridges just north of its mouth. The direct distance between the source and mouth is only 16.9 miles (27.2 km). The difference in elevation between source and mouth, 1,225 feet (373 m), divided by the length of the creek, 22.9 miles (36.9 km), gives the average drop in elevation per unit length of creek or relief ratio of 53.5 feet per mile (10.1 m/km). The meander ratio is 1.08, so the creek is fairly straight in its bed.
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