1820
A list of the 61 largest cities from the 1820 census is available from the Census Bureau and the source of this information.
| Rank | City | State | Population | Notes |
| 1 | New York | New York | 123,706 | New York was the first city to surpass 100,000 people in population. |
| 2 | Philadelphia | Pennsylvania | 63,802 | |
| 3 | Baltimore | Maryland | 62,738 | |
| 4 | Boston | Massachusetts | 43,298 | |
| 5 | New Orleans | Louisiana | 27,176 | |
| 6 | Charleston | South Carolina | 24,780 | |
| 7 | Northern Liberties | Pennsylvania | 19,678 | Now a neighborhood of Philadelphia. |
| 8 | Southwark | Pennsylvania | 14,713 | Now a neighborhood in South Philadelphia. |
| 9 | Washington | District of Columbia | 13,247 | First appearance of the new capital in the top 10. Would disappear from the list by next census and not appear on top 10 till 1950. |
| 10 | Salem | Massachusetts | 12,731 | Listed as a town in 1820 census. Today, Salem is a city. |
Read more about this topic: Largest Cities In The United States By Population By Decade