1800
Source data for population is available from the Census Bureau.
| Rank | City | State | Population | Notes |
| 1 | New York | New York | 60,515 | |
| 2 | Philadelphia | Pennsylvania | 41,220 | |
| 3 | Baltimore | Maryland | 26,514 | |
| 4 | Boston | Massachusetts | 24,937 | |
| 5 | Charleston | South Carolina | 18,824 | |
| 6 | Northern Liberties | Pennsylvania | 10,718 | Now a neighborhood in Philadelphia. |
| 7 | Southwark | Pennsylvania | 9,621 | Now a neighborhood in South Philadelphia. |
| 8 | Salem | Massachusetts | 9,457 | Listed as a town. Today, Salem is a city. |
| 9 | Providence | Rhode Island | 7,614 | Last appearance in top ten. Drops to 11th by 1810. |
| 10 | Norfolk | Virginia | 6,926 | Listed as a borough. Now an independent city. |
Read more about this topic: Largest Cities In The United States By Population By Decade